The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange
Rapid and efficient iridium‐mediated hydrogen‐tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(I) phosphine systems for ortho‐directed isotopic exchange is described to provide the reader with a c...
Gespeichert in:
| Veröffentlicht in: | Journal of labelled compounds & radiopharmaceuticals 2010-09, Vol.53 (11-12), p.645-657 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 657 |
|---|---|
| container_issue | 11-12 |
| container_start_page | 645 |
| container_title | Journal of labelled compounds & radiopharmaceuticals |
| container_volume | 53 |
| creator | Salter, Rhys |
| description | Rapid and efficient iridium‐mediated hydrogen‐tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(I) phosphine systems for ortho‐directed isotopic exchange is described to provide the reader with a comprehensive introduction to the area and to serve as a starting point for experimental investigators. Examples of useful catalyst systems and their application to different substrates types as well as potential areas for further development are discussed. Copyright © 2010 John Wiley & Sons, Ltd.
Iridium(I) phosphine containing complexes can be used for ortho‐exchange deuteration and tritiation of aromatic substrates containing the appropriate directing group (DG). The labeling takes place most efficiently in DCM and uses isotopic hydrogen gas as the isotope donor. A review of the development and use of these catalytic systems is described to serve as an introduction to the area and provide a starting point for experimental investigators. Copyright © 2010 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/jlcr.1814 |
| format | Article |
| fullrecord | <record><control><sourceid>istex_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_jlcr_1814</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>ark_67375_WNG_1NZWR3HQ_J</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3074-ebc6734aa1c5221a10e4575d5fbc7e18185350614fe263e640a1cfa4244e99833</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EEqWw4A-8pIu0duy8lqiCPlQVURVVYmO58aRxSeLITqH5e1K1YsdqFnPu1cxB6JGSISXEH-2L1A5pTPkV6lGSJB5lnF-jHmGh7_GYsFt059yekG7HeQ-pdQ5YwTcUpi6harCsFD44wCbD2mqlD-XTbIDr3Lg61xVg17oGSoczY7GxTW48pS2kDSict8qaHVSedqYxNWA4prmsdnCPbjJZOHi4zD76eH1Zj6fe4m0yGz8vvJSRiHuwTcOIcSlpGvg-lZQAD6JABdk2jaB7Kg5YQELKM_BDBiEnHZlJ7nMOSRIz1keDc29qjXMWMlFbXUrbCkrESY846REnPR07OrM_uoD2f1DMF-PVJeGdE7ozcPxLSPslurOjQGyWE0GXn5sVm76LOfsFeZF3rQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange</title><source>Access via Wiley Online Library</source><creator>Salter, Rhys</creator><creatorcontrib>Salter, Rhys</creatorcontrib><description>Rapid and efficient iridium‐mediated hydrogen‐tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(I) phosphine systems for ortho‐directed isotopic exchange is described to provide the reader with a comprehensive introduction to the area and to serve as a starting point for experimental investigators. Examples of useful catalyst systems and their application to different substrates types as well as potential areas for further development are discussed. Copyright © 2010 John Wiley & Sons, Ltd.
Iridium(I) phosphine containing complexes can be used for ortho‐exchange deuteration and tritiation of aromatic substrates containing the appropriate directing group (DG). The labeling takes place most efficiently in DCM and uses isotopic hydrogen gas as the isotope donor. A review of the development and use of these catalytic systems is described to serve as an introduction to the area and provide a starting point for experimental investigators. Copyright © 2010 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0362-4803</identifier><identifier>EISSN: 1099-1344</identifier><identifier>DOI: 10.1002/jlcr.1814</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>catalyst development ; deuterium labeling ; iridium catalyst ; isotope exchange ; ortho-labeling ; regioselective labeling ; tritium labeling</subject><ispartof>Journal of labelled compounds & radiopharmaceuticals, 2010-09, Vol.53 (11-12), p.645-657</ispartof><rights>Copyright © 2010 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3074-ebc6734aa1c5221a10e4575d5fbc7e18185350614fe263e640a1cfa4244e99833</citedby><cites>FETCH-LOGICAL-c3074-ebc6734aa1c5221a10e4575d5fbc7e18185350614fe263e640a1cfa4244e99833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjlcr.1814$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjlcr.1814$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Salter, Rhys</creatorcontrib><title>The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange</title><title>Journal of labelled compounds & radiopharmaceuticals</title><addtitle>J Label Compd Radiopharm</addtitle><description>Rapid and efficient iridium‐mediated hydrogen‐tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(I) phosphine systems for ortho‐directed isotopic exchange is described to provide the reader with a comprehensive introduction to the area and to serve as a starting point for experimental investigators. Examples of useful catalyst systems and their application to different substrates types as well as potential areas for further development are discussed. Copyright © 2010 John Wiley & Sons, Ltd.
Iridium(I) phosphine containing complexes can be used for ortho‐exchange deuteration and tritiation of aromatic substrates containing the appropriate directing group (DG). The labeling takes place most efficiently in DCM and uses isotopic hydrogen gas as the isotope donor. A review of the development and use of these catalytic systems is described to serve as an introduction to the area and provide a starting point for experimental investigators. Copyright © 2010 John Wiley & Sons, Ltd.</description><subject>catalyst development</subject><subject>deuterium labeling</subject><subject>iridium catalyst</subject><subject>isotope exchange</subject><subject>ortho-labeling</subject><subject>regioselective labeling</subject><subject>tritium labeling</subject><issn>0362-4803</issn><issn>1099-1344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EEqWw4A-8pIu0duy8lqiCPlQVURVVYmO58aRxSeLITqH5e1K1YsdqFnPu1cxB6JGSISXEH-2L1A5pTPkV6lGSJB5lnF-jHmGh7_GYsFt059yekG7HeQ-pdQ5YwTcUpi6harCsFD44wCbD2mqlD-XTbIDr3Lg61xVg17oGSoczY7GxTW48pS2kDSict8qaHVSedqYxNWA4prmsdnCPbjJZOHi4zD76eH1Zj6fe4m0yGz8vvJSRiHuwTcOIcSlpGvg-lZQAD6JABdk2jaB7Kg5YQELKM_BDBiEnHZlJ7nMOSRIz1keDc29qjXMWMlFbXUrbCkrESY846REnPR07OrM_uoD2f1DMF-PVJeGdE7ozcPxLSPslurOjQGyWE0GXn5sVm76LOfsFeZF3rQ</recordid><startdate>201009</startdate><enddate>201009</enddate><creator>Salter, Rhys</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201009</creationdate><title>The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange</title><author>Salter, Rhys</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3074-ebc6734aa1c5221a10e4575d5fbc7e18185350614fe263e640a1cfa4244e99833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>catalyst development</topic><topic>deuterium labeling</topic><topic>iridium catalyst</topic><topic>isotope exchange</topic><topic>ortho-labeling</topic><topic>regioselective labeling</topic><topic>tritium labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Salter, Rhys</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Salter, Rhys</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange</atitle><jtitle>Journal of labelled compounds & radiopharmaceuticals</jtitle><addtitle>J Label Compd Radiopharm</addtitle><date>2010-09</date><risdate>2010</risdate><volume>53</volume><issue>11-12</issue><spage>645</spage><epage>657</epage><pages>645-657</pages><issn>0362-4803</issn><eissn>1099-1344</eissn><abstract>Rapid and efficient iridium‐mediated hydrogen‐tritium exchange labeling of pharmaceutical compounds is a key methodology in the life sciences industry. A review of the development and use of iridium(I) phosphine systems for ortho‐directed isotopic exchange is described to provide the reader with a comprehensive introduction to the area and to serve as a starting point for experimental investigators. Examples of useful catalyst systems and their application to different substrates types as well as potential areas for further development are discussed. Copyright © 2010 John Wiley & Sons, Ltd.
Iridium(I) phosphine containing complexes can be used for ortho‐exchange deuteration and tritiation of aromatic substrates containing the appropriate directing group (DG). The labeling takes place most efficiently in DCM and uses isotopic hydrogen gas as the isotope donor. A review of the development and use of these catalytic systems is described to serve as an introduction to the area and provide a starting point for experimental investigators. Copyright © 2010 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/jlcr.1814</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0362-4803 |
| ispartof | Journal of labelled compounds & radiopharmaceuticals, 2010-09, Vol.53 (11-12), p.645-657 |
| issn | 0362-4803 1099-1344 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jlcr_1814 |
| source | Access via Wiley Online Library |
| subjects | catalyst development deuterium labeling iridium catalyst isotope exchange ortho-labeling regioselective labeling tritium labeling |
| title | The development and use of iridium(I) phosphine systems for ortho-directed hydrogen-isotope exchange |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T11%3A15%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-istex_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20development%20and%20use%20of%20iridium(I)%20phosphine%20systems%20for%20ortho-directed%20hydrogen-isotope%20exchange&rft.jtitle=Journal%20of%20labelled%20compounds%20&%20radiopharmaceuticals&rft.au=Salter,%20Rhys&rft.date=2010-09&rft.volume=53&rft.issue=11-12&rft.spage=645&rft.epage=657&rft.pages=645-657&rft.issn=0362-4803&rft.eissn=1099-1344&rft_id=info:doi/10.1002/jlcr.1814&rft_dat=%3Cistex_cross%3Eark_67375_WNG_1NZWR3HQ_J%3C/istex_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |