Synthesis of [14C] - and [13C6]-labeled tipranavir and its potential hydroxyl metabolite and the glucuronide conjugate

Tipranavir or Aptivus® is a non‐peptidic protease inhibitor approved for the combination treatment with ritonavir of HIV infection. Tipranavir labeled with radioactive and stable isotopes of carbon was required for drug metabolism (excretion, distribution, and absorption) studies and to develop bioa...

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Veröffentlicht in:	Journal of labelled compounds & radiopharmaceuticals 2008-07, Vol.51 (8), p.314-320
Hauptverfasser:	Latli, Bachir, Hrapchak, Matt, Easter, John A., Stolle, Wayne T., Grozinger, Karl, Krishnamurthy, Dhileepkumar, Senanayake, Chris H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences carbon13 carbon14 Contrast media. Radiopharmaceuticals HIV-AIDS Medical sciences Pharmacology. Drug treatments radiosynthesis tipranavir
Online-Zugang:	Volltext
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