Preparation and use of chloromethyl (−)-menthyl ether in the synthesis of optically pure α-branched α-amino nitriles

The synthesis of optically pure chloromethyl (−)‐menthyl ether (2b) and its use in the synthesis of di‐(−)‐menthyl acetal (−)‐menthyl (+)‐menthyl acetals are described. The diastereomeric mixed acetals 7a, b and 8a, b are easily obtainable from the nitrones 5 and 6, KCN and 2b. The mixtures of diast...

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Veröffentlicht in:	Liebigs Annalen der Chemie 1991-04, Vol.1991 (4), p.375-379
Hauptverfasser:	Shatzmiller, Shimon, Dolithzky, Ben-Zion, Bahar, Eliezer
Format:	Artikel
Sprache:	eng
Schlagworte:	2-methyl Chemistry Chiral chloromethyl ethers Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Organic chemistry Pipecolic acid Pipecolic acid, 2‐methyl Preparations and properties Proline Proline, α‐methyl α-methyl
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