Synthese von (R)‐Lasiodiplodin aus Polyhydroxybuttersäure

Synthese von (R)‐Lasiodiplodin aus Polyhydroxybuttersäure

Synthesis of (R)‐Lasiodiplodin from Polyhydroxybutyric Acid The twelve‐membered macrolide (R)‐lasiodiplodin (1), a fungal metabolite of Botrysdiplodia theobromae, has been synthesized in a nine‐step procedure. (R)‐1,3‐Butanediol (6), which is easily available by reductive depolymerization of the bio...

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Veröffentlicht in:Liebigs Annalen der Chemie 1990-06, Vol.1990 (6), p.513-517
Hauptverfasser: Braun, Manfred, Mahler, Ulrike, Houben, Sabine
Format: Artikel
Sprache:eng
Schlagworte:
(R)‐Lasiodiplodin
Botrysdiplodia theobromae Pat
Macrolide
Polyhydroxybutyric acid
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Zusammenfassung:Synthesis of (R)‐Lasiodiplodin from Polyhydroxybutyric Acid The twelve‐membered macrolide (R)‐lasiodiplodin (1), a fungal metabolite of Botrysdiplodia theobromae, has been synthesized in a nine‐step procedure. (R)‐1,3‐Butanediol (6), which is easily available by reductive depolymerization of the biopolymer polyhydroxybutyric acid (PHB), proves itself as a suitable enantiomerically pure building block.
ISSN:0170-2041
1099-0690
DOI:10.1002/jlac.199019900198