Novel, diastereoselective synthesis of 3-amino-1-alkanols

Benzaldehyde adds to 1‐pyrrolidinylcyclohexene under mild conditions giving the amino ketone 3a. The unstable ketone was reduced to the epimeric alcohols 4 and 5, the stereochemistry of which was determined by 2D‐NMR correlation spectroscopy.

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Bibliographische Detailangaben
Veröffentlicht in:	Liebigs Annalen der Chemie 1990-02, Vol.1990 (2), p.211-212
Hauptverfasser:	Oszbach, György, Neszmélyi, András
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds Alicyclic compounds, terpenoids, prostaglandins, steroids Amino alcohols Amino alcohols, stereoselective reduction Chemistry Exact sciences and technology Organic chemistry Preparations and properties stereoselective reduction
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Beschreibung
Zusammenfassung:	Benzaldehyde adds to 1‐pyrrolidinylcyclohexene under mild conditions giving the amino ketone 3a. The unstable ketone was reduced to the epimeric alcohols 4 and 5, the stereochemistry of which was determined by 2D‐NMR correlation spectroscopy.
ISSN:	0170-2041 1099-0690
DOI:	10.1002/jlac.199019900138