Improved automated simultaneous determination of isosorbide dinitrate and its metabolites in plasma by capillary column gas chromatography
An automated specific and sensitive method for the simultaneous determination of isosorbide dinitrate and its metabolites isosorbide‐2‐mononitrate, isosorbide‐5‐mononitrate, isomannide mononitrate, and isoidide mononitrate at concentrations down to 0.5, 1, 3, 2, and 2 ng/ml, respectively, in human p...
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| Veröffentlicht in: | Journal of high resolution chromatography 1984-02, Vol.7 (2), p.58-65 |
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| container_end_page | 65 |
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| container_issue | 2 |
| container_start_page | 58 |
| container_title | Journal of high resolution chromatography |
| container_volume | 7 |
| creator | Lutz, D. Rasper, J. Gielsdorf, W. Settlage, J. A. Jaeger, H. |
| description | An automated specific and sensitive method for the simultaneous determination of isosorbide dinitrate and its metabolites isosorbide‐2‐mononitrate, isosorbide‐5‐mononitrate, isomannide mononitrate, and isoidide mononitrate at concentrations down to 0.5, 1, 3, 2, and 2 ng/ml, respectively, in human plasma is described. The procedure involves the extraction of the drug and its metabolites together with their internal standards isomannide dinitrate and o‐nitrobenzyl alcohol from plasma with dicholromethane.
The analysis is carried out by fused silica capillary gas chromatography using a 63Ni‐electron capture detector. The method is applied to the pharmacokinetics of isosorbide dinitrate in humans. |
| doi_str_mv | 10.1002/jhrc.1240070202 |
| format | Article |
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The analysis is carried out by fused silica capillary gas chromatography using a 63Ni‐electron capture detector. The method is applied to the pharmacokinetics of isosorbide dinitrate in humans.</description><identifier>ISSN: 0935-6304</identifier><identifier>ISSN: 0344-7138</identifier><identifier>EISSN: 1521-4168</identifier><identifier>DOI: 10.1002/jhrc.1240070202</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Analysis ; Biological and medical sciences ; Capillary ; Capillary, fused silica ; fused silica ; Gas chromatography/ECD ; General pharmacology ; Human plasma ; Isosorbide dinitrate ; Isosorbide-/isomannide-/isoidide-mononitrates ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Journal of high resolution chromatography, 1984-02, Vol.7 (2), p.58-65</ispartof><rights>Copyright © 1984 Dr. Alfred Huethig Publishers</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3582-de8b4c1248a3ece810f19c23f082e1d9fc3f9fd6bf1f0f2ad8fa7e097e2f5a0b3</citedby><cites>FETCH-LOGICAL-c3582-de8b4c1248a3ece810f19c23f082e1d9fc3f9fd6bf1f0f2ad8fa7e097e2f5a0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhrc.1240070202$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhrc.1240070202$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9636812$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Lutz, D.</creatorcontrib><creatorcontrib>Rasper, J.</creatorcontrib><creatorcontrib>Gielsdorf, W.</creatorcontrib><creatorcontrib>Settlage, J. A.</creatorcontrib><creatorcontrib>Jaeger, H.</creatorcontrib><title>Improved automated simultaneous determination of isosorbide dinitrate and its metabolites in plasma by capillary column gas chromatography</title><title>Journal of high resolution chromatography</title><addtitle>J. High Resol. Chromatogr</addtitle><description>An automated specific and sensitive method for the simultaneous determination of isosorbide dinitrate and its metabolites isosorbide‐2‐mononitrate, isosorbide‐5‐mononitrate, isomannide mononitrate, and isoidide mononitrate at concentrations down to 0.5, 1, 3, 2, and 2 ng/ml, respectively, in human plasma is described. The procedure involves the extraction of the drug and its metabolites together with their internal standards isomannide dinitrate and o‐nitrobenzyl alcohol from plasma with dicholromethane.
The analysis is carried out by fused silica capillary gas chromatography using a 63Ni‐electron capture detector. The method is applied to the pharmacokinetics of isosorbide dinitrate in humans.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Capillary</subject><subject>Capillary, fused silica</subject><subject>fused silica</subject><subject>Gas chromatography/ECD</subject><subject>General pharmacology</subject><subject>Human plasma</subject><subject>Isosorbide dinitrate</subject><subject>Isosorbide-/isomannide-/isoidide-mononitrates</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0935-6304</issn><issn>0344-7138</issn><issn>1521-4168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNqFkEtvFDEQhC0EEkvCmasPXCdp2_MUJ7TKZhNCkEgQUi5Wjx9ZJ57xyPZC9i_wq5nVoiBOnLoO_VV1FyHvGJwwAH76sInqhPESoAEO_AVZsIqzomR1-5IsoBNVUQsoX5M3KT0AQNeVbEF-XQxTDD-MprjNYcA8q-SGrc84mrBNVJts4uBGzC6MNFjqUkgh9k4bqt3ocpwZiqOmLic6mIx98C6bRN1IJ49pQNrvqMLJeY9xVsFvh5HeY6JqE_eR4T7itNkdk1cWfTJv_8wj8m11drtcF1dfzi-WH68KJaqWF9q0fanmR1sURpmWgWWd4sJCyw3TnVXCdlbXvWUWLEfdWmwMdI3htkLoxRE5PfiqGFKKxsopumE-TTKQ-yrlvkr5t8qZeH8gJkwKvY04Kpeesa4Wdcv2ax8Oaz-dN7v_ucrL9dflPyHFgXYpm6dnGuOjrBvRVPL79blcf7r5LFZ3d3IlfgMXAJqA</recordid><startdate>198402</startdate><enddate>198402</enddate><creator>Lutz, D.</creator><creator>Rasper, J.</creator><creator>Gielsdorf, W.</creator><creator>Settlage, J. A.</creator><creator>Jaeger, H.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Hüthig</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198402</creationdate><title>Improved automated simultaneous determination of isosorbide dinitrate and its metabolites in plasma by capillary column gas chromatography</title><author>Lutz, D. ; Rasper, J. ; Gielsdorf, W. ; Settlage, J. A. ; Jaeger, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3582-de8b4c1248a3ece810f19c23f082e1d9fc3f9fd6bf1f0f2ad8fa7e097e2f5a0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Capillary</topic><topic>Capillary, fused silica</topic><topic>fused silica</topic><topic>Gas chromatography/ECD</topic><topic>General pharmacology</topic><topic>Human plasma</topic><topic>Isosorbide dinitrate</topic><topic>Isosorbide-/isomannide-/isoidide-mononitrates</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lutz, D.</creatorcontrib><creatorcontrib>Rasper, J.</creatorcontrib><creatorcontrib>Gielsdorf, W.</creatorcontrib><creatorcontrib>Settlage, J. A.</creatorcontrib><creatorcontrib>Jaeger, H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of high resolution chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lutz, D.</au><au>Rasper, J.</au><au>Gielsdorf, W.</au><au>Settlage, J. A.</au><au>Jaeger, H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved automated simultaneous determination of isosorbide dinitrate and its metabolites in plasma by capillary column gas chromatography</atitle><jtitle>Journal of high resolution chromatography</jtitle><addtitle>J. High Resol. Chromatogr</addtitle><date>1984-02</date><risdate>1984</risdate><volume>7</volume><issue>2</issue><spage>58</spage><epage>65</epage><pages>58-65</pages><issn>0935-6304</issn><issn>0344-7138</issn><eissn>1521-4168</eissn><abstract>An automated specific and sensitive method for the simultaneous determination of isosorbide dinitrate and its metabolites isosorbide‐2‐mononitrate, isosorbide‐5‐mononitrate, isomannide mononitrate, and isoidide mononitrate at concentrations down to 0.5, 1, 3, 2, and 2 ng/ml, respectively, in human plasma is described. The procedure involves the extraction of the drug and its metabolites together with their internal standards isomannide dinitrate and o‐nitrobenzyl alcohol from plasma with dicholromethane.
The analysis is carried out by fused silica capillary gas chromatography using a 63Ni‐electron capture detector. The method is applied to the pharmacokinetics of isosorbide dinitrate in humans.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/jhrc.1240070202</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0935-6304 |
| ispartof | Journal of high resolution chromatography, 1984-02, Vol.7 (2), p.58-65 |
| issn | 0935-6304 0344-7138 1521-4168 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jhrc_1240070202 |
| source | Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Analysis Biological and medical sciences Capillary Capillary, fused silica fused silica Gas chromatography/ECD General pharmacology Human plasma Isosorbide dinitrate Isosorbide-/isomannide-/isoidide-mononitrates Medical sciences Pharmacology. Drug treatments |
| title | Improved automated simultaneous determination of isosorbide dinitrate and its metabolites in plasma by capillary column gas chromatography |
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