Synthesis and cytotoxicity of nitrogen mustard/tripolypyrrole conjugate
A series of nitrogen mustard derivatives were synthesized by chloroform reaction and coupling reaction using DCC/ HOBT as promoting additives. The structure of compound was confirmed by 1H NMR, 31P NMR, MS and IR. The data show that the nitrogen mustard with tripolypyrrole as the linker inhibits all...
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| Veröffentlicht in: | Journal of heterocyclic chemistry 2008-11, Vol.45 (6), p.1851-1854 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A series of nitrogen mustard derivatives were synthesized by chloroform reaction and coupling reaction using DCC/ HOBT as promoting additives. The structure of compound was confirmed by 1H NMR, 31P NMR, MS and IR. The data show that the nitrogen mustard with tripolypyrrole as the linker inhibits all the four tested cells and has the highest activity. |
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| ISSN: | 0022-152X 1943-5193 |
| DOI: | 10.1002/jhet.5570450647 |