One-pot synthesis of pyrido[2,3-d]pyrimidines via efficient three-component reaction in aqueous media

One-pot synthesis of pyrido[2,3-d]pyrimidines via efficient three-component reaction in aqueous media

A short and facile synthesis of pyrido[2,3‐d]pyrimidine derivatives was accomplished in good yields via the three‐component reaction of aldehydes, alkyl nitriles and aminopyrimidines in water in the presence of triethylbenzylammonium chloride (TEBAC). The structures of these compounds were character...

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Veröffentlicht in:Journal of heterocyclic chemistry 2007-09, Vol.44 (5), p.1083-1090
Hauptverfasser: Shi, Daqing, Ji, Shunjun, Niu, Lihui, Shi, Jingwen, Wang, Xiangshan
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container_end_page 1090
container_issue 5
container_start_page 1083
container_title Journal of heterocyclic chemistry
container_volume 44
creator Shi, Daqing
Ji, Shunjun
Niu, Lihui
Shi, Jingwen
Wang, Xiangshan
description A short and facile synthesis of pyrido[2,3‐d]pyrimidine derivatives was accomplished in good yields via the three‐component reaction of aldehydes, alkyl nitriles and aminopyrimidines in water in the presence of triethylbenzylammonium chloride (TEBAC). The structures of these compounds were characterized by elemental analysis, IR and 1H NMR spectra and further confirmed by single crystal X‐ray diffraction analysis.
doi_str_mv 10.1002/jhet.5570440517
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title One-pot synthesis of pyrido[2,3-d]pyrimidines via efficient three-component reaction in aqueous media
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