A facile one-pot synthesis of novel substituted 1,2,3,4-tetrahydropyrimidine, part 2: Synthesis of 1-(aralkyl/aryl)-3-(alkyl/aralkyl/aryl)-5-aroyl-1,2,3,4-tetrahydropyrimidines

A facile one-pot synthesis of novel substituted 1,2,3,4-tetrahydropyrimidine, part 2: Synthesis of 1-(aralkyl/aryl)-3-(alkyl/aralkyl/aryl)-5-aroyl-1,2,3,4-tetrahydropyrimidines

1‐(Aralkyl/aryl)‐3‐(alkyyaralkyl)‐5‐aroyl‐1,2,3,4‐tetrahydropyrimidines (2a‐c) have been synthesized by dethiomethylation of 5‐aroyl‐6‐methylthio‐1,2,3,4‐tetrahydropyrimidines (1a‐c). An alternative one‐pot synthetic strategy has been developed for the title compounds 2a‐t by the reaction of enamino...

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Veröffentlicht in:Journal of heterocyclic chemistry 2004-07, Vol.41 (4), p.627-631
Hauptverfasser: Chanda, Kaushik, Dutta, Milan Ch, Karim, Enamul, Vishwakarma, Jai N.
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container_issue 4
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container_title Journal of heterocyclic chemistry
container_volume 41
creator Chanda, Kaushik
Dutta, Milan Ch
Karim, Enamul
Vishwakarma, Jai N.
description 1‐(Aralkyl/aryl)‐3‐(alkyyaralkyl)‐5‐aroyl‐1,2,3,4‐tetrahydropyrimidines (2a‐c) have been synthesized by dethiomethylation of 5‐aroyl‐6‐methylthio‐1,2,3,4‐tetrahydropyrimidines (1a‐c). An alternative one‐pot synthetic strategy has been developed for the title compounds 2a‐t by the reaction of enaminones 3 with pri mary amine and formaldehyde in refluxing methanol in good yields.
doi_str_mv 10.1002/jhet.5570410425
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title A facile one-pot synthesis of novel substituted 1,2,3,4-tetrahydropyrimidine, part 2: Synthesis of 1-(aralkyl/aryl)-3-(alkyl/aralkyl/aryl)-5-aroyl-1,2,3,4-tetrahydropyrimidines
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