Synthesis of novel flavonoid derivatives as potential HIV- Integrase inhibitors

Synthesis of novel flavonoid derivatives as potential HIV- Integrase inhibitors

Eighteen novel flavonoid derivatives ‐ substituted chalcones and flavones were synthesized and characterized by using NMR, IR, UV/Vis spectroscopy and elemental analysis. The target compounds were achieved by using a sequence of simple and effective reactions starting from phloroglucinol. The initia...

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Veröffentlicht in:Journal of heterocyclic chemistry 2002-11, Vol.39 (6), p.1251-1258
Hauptverfasser: Mateeva, Nelly N., Kode, Rao N., Redda, Kinfe K.
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container_title Journal of heterocyclic chemistry
container_volume 39
creator Mateeva, Nelly N.
Kode, Rao N.
Redda, Kinfe K.
description Eighteen novel flavonoid derivatives ‐ substituted chalcones and flavones were synthesized and characterized by using NMR, IR, UV/Vis spectroscopy and elemental analysis. The target compounds were achieved by using a sequence of simple and effective reactions starting from phloroglucinol. The initial hydroxyl groups were protected by methylation and in the final flavones the 5‐OH group was selectively demethylated by means of AlBr3. 5‐methoxy flavones exhibit a strong fluorescence, which was quenched after the removal of the methyl group.
doi_str_mv 10.1002/jhet.5570390620
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title Synthesis of novel flavonoid derivatives as potential HIV- Integrase inhibitors
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