Synthesis and structural study of novel 1,4,5,6,7,8-hexahydroquinolines

Synthesis and structural study of novel 1,4,5,6,7,8-hexahydroquinolines

A new series of 1,4,5,6,7,8‐hexahydroquinolines (9a‐j) has been synthesized and their structural features studied by X‐ray analysis and theoretical calculations at semiempirical and ab initio levels. A good correlation is found between the most stable conformation predicted for compounds 9 and that...

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Veröffentlicht in:Journal of heterocyclic chemistry 2000-07, Vol.37 (4), p.735-742
Hauptverfasser: Suárez, Margarita, Verdecia, Yamila, Ochoa, Estael, Martín, Nazario, Martínez, Roberto, Quinteir, Margarita, Seoane, Carlos, Soto, José L., Novoa, Héctor, Blaton, Norbert, Peeters, Oswald M., De Ranter, Camiel
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container_end_page 742
container_issue 4
container_start_page 735
container_title Journal of heterocyclic chemistry
container_volume 37
creator Suárez, Margarita
Verdecia, Yamila
Ochoa, Estael
Martín, Nazario
Martínez, Roberto
Quinteir, Margarita
Seoane, Carlos
Soto, José L.
Novoa, Héctor
Blaton, Norbert
Peeters, Oswald M.
De Ranter, Camiel
description A new series of 1,4,5,6,7,8‐hexahydroquinolines (9a‐j) has been synthesized and their structural features studied by X‐ray analysis and theoretical calculations at semiempirical and ab initio levels. A good correlation is found between the most stable conformation predicted for compounds 9 and that obtained by experimental X‐ray diffraction for 9h. The obtained geometrical features for 9 are similar to those found for other related active calcium modulators.
doi_str_mv 10.1002/jhet.5570370411
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title Synthesis and structural study of novel 1,4,5,6,7,8-hexahydroquinolines
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