Reaction of 4,5,6-triaminopyrimidine and 2,4,5,6-tetraaminopyrimidine with 3-dimethylaminopropiophenones. Synthesis of new 4-aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines

Reaction of 4,5,6-triaminopyrimidine and 2,4,5,6-tetraaminopyrimidine with 3-dimethylaminopropiophenones. Synthesis of new 4-aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines

Several new 6‐amino‐ and 6,8‐diamino‐4‐aryl‐2,3‐dihydropyrimido[4,5‐b][1,4]diazepines were obtained from the reaction of 4,5,6‐triaminopyrimidine 1a and 2,4,5,6‐tetraaminopyrimidine 1b with one equivalent of 3‐dimethylaminopropiophenones 2 in absolute ethanol. Structure analysis of 6‐amino‐ and 6,8‐...

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Veröffentlicht in:Journal of heterocyclic chemistry 2000-03, Vol.37 (2), p.401-403
Hauptverfasser: Braulio, Insuasty O., Henry, Insuasty I., Jairo, Quiroga P., Saitz, Claudio, Jullian, Carolina
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container_end_page 403
container_issue 2
container_start_page 401
container_title Journal of heterocyclic chemistry
container_volume 37
creator Braulio, Insuasty O.
Henry, Insuasty I.
Jairo, Quiroga P.
Saitz, Claudio
Jullian, Carolina
description Several new 6‐amino‐ and 6,8‐diamino‐4‐aryl‐2,3‐dihydropyrimido[4,5‐b][1,4]diazepines were obtained from the reaction of 4,5,6‐triaminopyrimidine 1a and 2,4,5,6‐tetraaminopyrimidine 1b with one equivalent of 3‐dimethylaminopropiophenones 2 in absolute ethanol. Structure analysis of 6‐amino‐ and 6,8‐diamino‐4‐aryl‐2,3‐dihydropyrimido[4,5‐b][1,4]diazepines 3a‐i, determined by detailed nmr measurements, reveals a high regioselectivity of this reaction.
doi_str_mv 10.1002/jhet.5570370228
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title Reaction of 4,5,6-triaminopyrimidine and 2,4,5,6-tetraaminopyrimidine with 3-dimethylaminopropiophenones. Synthesis of new 4-aryl-2,3-dihydropyrimido[4,5-b][1,4]diazepines
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