Diastereoselective synthesis of cis-3- and 3,5-alkylpyrrolizidines

Cis‐3 and 3,5‐substituted pyrrolizidines can be prepared from β‐enaminolactones. Substituted pyrrolidinoketones lead to these compounds by an amino reductive annelation with a low diastereomeric excess, but a best access to these azabicycles consists in preparing cis‐2,5‐disubstituted pyrrolidines w...

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Veröffentlicht in:	Journal of heterocyclic chemistry 1998-03, Vol.35 (2), p.371-376
Hauptverfasser:	Provot, Olivier, Célérier, Jean-Pierre, Lhommet, GÉRard
Format:	Artikel
Sprache:	eng
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container_title	Journal of heterocyclic chemistry
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creator	Provot, Olivier Célérier, Jean-Pierre Lhommet, GÉRard
description	Cis‐3 and 3,5‐substituted pyrrolizidines can be prepared from β‐enaminolactones. Substituted pyrrolidinoketones lead to these compounds by an amino reductive annelation with a low diastereomeric excess, but a best access to these azabicycles consists in preparing cis‐2,5‐disubstituted pyrrolidines which are then transformed into the expected heterocycles.
doi_str_mv	10.1002/jhet.5570350219
format	Article
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title	Diastereoselective synthesis of cis-3- and 3,5-alkylpyrrolizidines
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