Effect of Restraint Stress on Lead-Induced Male Reproductive Toxicity in Rats
ABSTRACT This study was undertaken to investigate whether chronic immobilization stress interferes with lead‐induced reproductive toxicity in rats. Early pubertal male Wistar rats were subjected to either restraint stress (5 hr/day) or maintained on lead (0.15%) containing water or both for 60 days....
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| Veröffentlicht in: | Journal of experimental zoology. Part A, Ecological genetics and physiology Ecological genetics and physiology, 2012-08, Vol.317 (7), p.455-465 |
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| container_title | Journal of experimental zoology. Part A, Ecological genetics and physiology |
| container_volume | 317 |
| creator | HARI PRIYA, P. REDDY, P. SREENIVASULA |
| description | ABSTRACT
This study was undertaken to investigate whether chronic immobilization stress interferes with lead‐induced reproductive toxicity in rats. Early pubertal male Wistar rats were subjected to either restraint stress (5 hr/day) or maintained on lead (0.15%) containing water or both for 60 days. Restraint stress or lead treatment significantly decreased the weight of the testes and epididymis. The daily sperm production, epididymal sperm count, sperm motility, and sperm viability were also decreased after exposure to lead or subjected to restraint stress. The levels of serum testosterone and also activity levels of testicular hydroxysteroid dehydrogenases were significantly decreased with a significant increase in the serum follicle stimulating and luteinizing hormone levels in rats exposed to lead or restraint stress indicating decreased steroidogenesis. A significant increase in lipid peroxidation levels and decrease in catalase and superoxide dismutase activity levels were observed in the testes of rats subjected to restraint stress or exposed to lead indicating increased oxidative stress. Extensive histopathological malformations were observed in the testis of the treated rats. From the findings, the study suggests that restraint stress or exposure to lead affects male reproduction in rats by inducing oxidative stress followed by decreasing steroidogenesis and spermatogenesis. A significant decrease in spermatogenesis and steroidogenesis was also observed in rats subjected to both restraint stress and lead treatment as compared to lead alone treated rats indicating immobilization stress augments lead‐induced testicular and epididymal toxicity in rats. J. Exp. Zool. 000A:1‐11, 2012. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jez.1738 |
| format | Article |
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This study was undertaken to investigate whether chronic immobilization stress interferes with lead‐induced reproductive toxicity in rats. Early pubertal male Wistar rats were subjected to either restraint stress (5 hr/day) or maintained on lead (0.15%) containing water or both for 60 days. Restraint stress or lead treatment significantly decreased the weight of the testes and epididymis. The daily sperm production, epididymal sperm count, sperm motility, and sperm viability were also decreased after exposure to lead or subjected to restraint stress. The levels of serum testosterone and also activity levels of testicular hydroxysteroid dehydrogenases were significantly decreased with a significant increase in the serum follicle stimulating and luteinizing hormone levels in rats exposed to lead or restraint stress indicating decreased steroidogenesis. A significant increase in lipid peroxidation levels and decrease in catalase and superoxide dismutase activity levels were observed in the testes of rats subjected to restraint stress or exposed to lead indicating increased oxidative stress. Extensive histopathological malformations were observed in the testis of the treated rats. From the findings, the study suggests that restraint stress or exposure to lead affects male reproduction in rats by inducing oxidative stress followed by decreasing steroidogenesis and spermatogenesis. A significant decrease in spermatogenesis and steroidogenesis was also observed in rats subjected to both restraint stress and lead treatment as compared to lead alone treated rats indicating immobilization stress augments lead‐induced testicular and epididymal toxicity in rats. J. Exp. Zool. 000A:1‐11, 2012. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1932-5223</identifier><identifier>EISSN: 1932-5231</identifier><identifier>DOI: 10.1002/jez.1738</identifier><identifier>PMID: 22753343</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Animals ; Catalase - metabolism ; Epididymis - drug effects ; Epididymis - physiology ; Histocytochemistry ; Hydroxysteroid Dehydrogenases - metabolism ; Lead - toxicity ; Male ; Organ Size - drug effects ; Organ Size - physiology ; Oxidative Stress - physiology ; Random Allocation ; Rats ; Rats, Wistar ; Restraint, Physical - physiology ; Spermatozoa - drug effects ; Spermatozoa - physiology ; Superoxide Dismutase - metabolism ; Testis - drug effects ; Testis - physiology ; Thiobarbituric Acid Reactive Substances - metabolism</subject><ispartof>Journal of experimental zoology. Part A, Ecological genetics and physiology, 2012-08, Vol.317 (7), p.455-465</ispartof><rights>2012 WILEY PERIODICALS, INC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4258-9cbbe7912f3227846b4f1dd4d0fb8a012cfe84de2ff357469f339619c88e3c573</citedby><cites>FETCH-LOGICAL-c4258-9cbbe7912f3227846b4f1dd4d0fb8a012cfe84de2ff357469f339619c88e3c573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjez.1738$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjez.1738$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22753343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HARI PRIYA, P.</creatorcontrib><creatorcontrib>REDDY, P. SREENIVASULA</creatorcontrib><title>Effect of Restraint Stress on Lead-Induced Male Reproductive Toxicity in Rats</title><title>Journal of experimental zoology. Part A, Ecological genetics and physiology</title><addtitle>J. Exp. Zool</addtitle><description>ABSTRACT
This study was undertaken to investigate whether chronic immobilization stress interferes with lead‐induced reproductive toxicity in rats. Early pubertal male Wistar rats were subjected to either restraint stress (5 hr/day) or maintained on lead (0.15%) containing water or both for 60 days. Restraint stress or lead treatment significantly decreased the weight of the testes and epididymis. The daily sperm production, epididymal sperm count, sperm motility, and sperm viability were also decreased after exposure to lead or subjected to restraint stress. The levels of serum testosterone and also activity levels of testicular hydroxysteroid dehydrogenases were significantly decreased with a significant increase in the serum follicle stimulating and luteinizing hormone levels in rats exposed to lead or restraint stress indicating decreased steroidogenesis. A significant increase in lipid peroxidation levels and decrease in catalase and superoxide dismutase activity levels were observed in the testes of rats subjected to restraint stress or exposed to lead indicating increased oxidative stress. Extensive histopathological malformations were observed in the testis of the treated rats. From the findings, the study suggests that restraint stress or exposure to lead affects male reproduction in rats by inducing oxidative stress followed by decreasing steroidogenesis and spermatogenesis. A significant decrease in spermatogenesis and steroidogenesis was also observed in rats subjected to both restraint stress and lead treatment as compared to lead alone treated rats indicating immobilization stress augments lead‐induced testicular and epididymal toxicity in rats. J. Exp. Zool. 000A:1‐11, 2012. © 2012 Wiley Periodicals, Inc.</description><subject>Animals</subject><subject>Catalase - metabolism</subject><subject>Epididymis - drug effects</subject><subject>Epididymis - physiology</subject><subject>Histocytochemistry</subject><subject>Hydroxysteroid Dehydrogenases - metabolism</subject><subject>Lead - toxicity</subject><subject>Male</subject><subject>Organ Size - drug effects</subject><subject>Organ Size - physiology</subject><subject>Oxidative Stress - physiology</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Restraint, Physical - physiology</subject><subject>Spermatozoa - drug effects</subject><subject>Spermatozoa - physiology</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Testis - drug effects</subject><subject>Testis - physiology</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>1932-5223</issn><issn>1932-5231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1PAjEQBuDGaETRxF9gevSy2Ha6X0dFRAxoAhgTL023O00WYZdsi4K_3iUgN08zkzx5M3kJueKswxkTtzP86fAYkiNyxlMQQSiAHx92AS1y7tyMsVCyVJ6SlhBxCCDhjIx61qLxtLJ0jM7Xuig9nfganaNVSYeo82BQ5iuDOR3pOTZqWVfN7YsvpNNqXZjCb2hR0rH27oKcWD13eLmfbfL22Jt2n4Lha3_QvRsGRoowCVKTZRinXFhoPklklEnL81zmzGaJZlwYi4nMUVgLYSyj1AKkEU9NkiCYMIY2udnlmrpyrkarlnWx0PVGcaa2jaimEbVtpKHXO7pcZQvMD_CvggYEO_BdzHHzb5B67n3sA_e-cB7XB6_rTxXFEIfq_aWvJvddAdP-g0rgFzUueLI</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>HARI PRIYA, P.</creator><creator>REDDY, P. SREENIVASULA</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201208</creationdate><title>Effect of Restraint Stress on Lead-Induced Male Reproductive Toxicity in Rats</title><author>HARI PRIYA, P. ; REDDY, P. SREENIVASULA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4258-9cbbe7912f3227846b4f1dd4d0fb8a012cfe84de2ff357469f339619c88e3c573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Catalase - metabolism</topic><topic>Epididymis - drug effects</topic><topic>Epididymis - physiology</topic><topic>Histocytochemistry</topic><topic>Hydroxysteroid Dehydrogenases - metabolism</topic><topic>Lead - toxicity</topic><topic>Male</topic><topic>Organ Size - drug effects</topic><topic>Organ Size - physiology</topic><topic>Oxidative Stress - physiology</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Restraint, Physical - physiology</topic><topic>Spermatozoa - drug effects</topic><topic>Spermatozoa - physiology</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Testis - drug effects</topic><topic>Testis - physiology</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HARI PRIYA, P.</creatorcontrib><creatorcontrib>REDDY, P. SREENIVASULA</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of experimental zoology. Part A, Ecological genetics and physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HARI PRIYA, P.</au><au>REDDY, P. SREENIVASULA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Restraint Stress on Lead-Induced Male Reproductive Toxicity in Rats</atitle><jtitle>Journal of experimental zoology. Part A, Ecological genetics and physiology</jtitle><addtitle>J. Exp. Zool</addtitle><date>2012-08</date><risdate>2012</risdate><volume>317</volume><issue>7</issue><spage>455</spage><epage>465</epage><pages>455-465</pages><issn>1932-5223</issn><eissn>1932-5231</eissn><abstract>ABSTRACT
This study was undertaken to investigate whether chronic immobilization stress interferes with lead‐induced reproductive toxicity in rats. Early pubertal male Wistar rats were subjected to either restraint stress (5 hr/day) or maintained on lead (0.15%) containing water or both for 60 days. Restraint stress or lead treatment significantly decreased the weight of the testes and epididymis. The daily sperm production, epididymal sperm count, sperm motility, and sperm viability were also decreased after exposure to lead or subjected to restraint stress. The levels of serum testosterone and also activity levels of testicular hydroxysteroid dehydrogenases were significantly decreased with a significant increase in the serum follicle stimulating and luteinizing hormone levels in rats exposed to lead or restraint stress indicating decreased steroidogenesis. A significant increase in lipid peroxidation levels and decrease in catalase and superoxide dismutase activity levels were observed in the testes of rats subjected to restraint stress or exposed to lead indicating increased oxidative stress. Extensive histopathological malformations were observed in the testis of the treated rats. From the findings, the study suggests that restraint stress or exposure to lead affects male reproduction in rats by inducing oxidative stress followed by decreasing steroidogenesis and spermatogenesis. A significant decrease in spermatogenesis and steroidogenesis was also observed in rats subjected to both restraint stress and lead treatment as compared to lead alone treated rats indicating immobilization stress augments lead‐induced testicular and epididymal toxicity in rats. J. Exp. Zool. 000A:1‐11, 2012. © 2012 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>22753343</pmid><doi>10.1002/jez.1738</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of experimental zoology. Part A, Ecological genetics and physiology, 2012-08, Vol.317 (7), p.455-465 |
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| subjects | Animals Catalase - metabolism Epididymis - drug effects Epididymis - physiology Histocytochemistry Hydroxysteroid Dehydrogenases - metabolism Lead - toxicity Male Organ Size - drug effects Organ Size - physiology Oxidative Stress - physiology Random Allocation Rats Rats, Wistar Restraint, Physical - physiology Spermatozoa - drug effects Spermatozoa - physiology Superoxide Dismutase - metabolism Testis - drug effects Testis - physiology Thiobarbituric Acid Reactive Substances - metabolism |
| title | Effect of Restraint Stress on Lead-Induced Male Reproductive Toxicity in Rats |
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