Endothelial dysfunction in patients with myocardial ischemia or infarction and nonobstructive coronary arteries
Purpose The syndromes of myocardial infarction/myocardial ischemia with No Obstructive Coronary Artery Disease (MINOCA/INOCA) are seen more and more often. Endothelial dysfunction (ED) leading to ischemic events has been reported in many of these patients. We aimed to compare patients with MINOCA an...
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| Veröffentlicht in: | Journal of clinical ultrasound 2021-05, Vol.49 (4), p.334-340 |
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| creator | Simsek, Ersin Cagri Sari, Cenk Kucukokur, Murat Ekmekci, Cenk Colak, Ayfer Ozdogan, Oner |
| description | Purpose
The syndromes of myocardial infarction/myocardial ischemia with No Obstructive Coronary Artery Disease (MINOCA/INOCA) are seen more and more often. Endothelial dysfunction (ED) leading to ischemic events has been reported in many of these patients. We aimed to compare patients with MINOCA and INOCA regarding brachial artery flow‐mediated endothelium‐dependent vasodilation (flow‐mediated dilation [FMD]) and plasma concentration of cardiotrophin‐1 (CT‐1).
Methods
We included 42 patients with MINOCA and 38 patients with INOCA. Endothelial function was assessed by measuring FMD% and nitroglycerin‐mediated dilatation (NMD%) in the brachial artery. The plasma level of CT‐1 was determined by solid‐phase enzyme‐linked immunosorbent assay.
Results
FMD% was significantly lower in MINOCA than in INOCA patients (6.45 ± 2.65 vs 8.94 ± 3.32, P |
| doi_str_mv | 10.1002/jcu.22902 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_jcu_22902</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2509220197</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-bfa758fb8cad921d94c7413a9ea9a6ecea77fa168bd31c412d518f4aff73f66c3</originalsourceid><addsrcrecordid>eNqNkU9rFTEUxYNY7LO68AvIgBtFps2fyWSylKFqS8GNXYc7mYSXx0zyTDIt79ub13l2IQiubgi_czn3HITeEXxJMKZXO71cUioxfYE2BEtRYyzbl2hTBqmp4OQcvU5phzFuOeev0DmjQrSM0Q0K134MeWsmB1M1HpJdvM4u-Mr5ag_ZGZ9T9ejytpoPQUMcj5xLemtmB1WIhbMQVwn4sfLBhyHluJSvB1PpEIOHeKggZhOdSW_QmYUpmbeneYHuv17_7L_Xdz--3fRf7mrNOKP1YEHwzg6dhlFSMspGi4YwkAYktEYbEMICabthZEQ3hI6cdLYBawWzbavZBfq47t3H8GsxKau5uDbTBN6EJSnaMNpxKTAp6Ie_0F1Yoi_uFOVYUoqJFIX6tFI6hpSisWof3VxOUwSrYwuqtKCeWijs-9PGZZjN-Ez-ib0A3Qo8miHYpEvM2jxjpSfOBe2YLC9MepfhmG8fFp-L9PP_Swt9daLdZA7_tqxu-_vV-2_D87R-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2509220197</pqid></control><display><type>article</type><title>Endothelial dysfunction in patients with myocardial ischemia or infarction and nonobstructive coronary arteries</title><source>Wiley Online Library - AutoHoldings Journals</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><creator>Simsek, Ersin Cagri ; Sari, Cenk ; Kucukokur, Murat ; Ekmekci, Cenk ; Colak, Ayfer ; Ozdogan, Oner</creator><creatorcontrib>Simsek, Ersin Cagri ; Sari, Cenk ; Kucukokur, Murat ; Ekmekci, Cenk ; Colak, Ayfer ; Ozdogan, Oner</creatorcontrib><description>Purpose
The syndromes of myocardial infarction/myocardial ischemia with No Obstructive Coronary Artery Disease (MINOCA/INOCA) are seen more and more often. Endothelial dysfunction (ED) leading to ischemic events has been reported in many of these patients. We aimed to compare patients with MINOCA and INOCA regarding brachial artery flow‐mediated endothelium‐dependent vasodilation (flow‐mediated dilation [FMD]) and plasma concentration of cardiotrophin‐1 (CT‐1).
Methods
We included 42 patients with MINOCA and 38 patients with INOCA. Endothelial function was assessed by measuring FMD% and nitroglycerin‐mediated dilatation (NMD%) in the brachial artery. The plasma level of CT‐1 was determined by solid‐phase enzyme‐linked immunosorbent assay.
Results
FMD% was significantly lower in MINOCA than in INOCA patients (6.45 ± 2.65 vs 8.94 ± 3.32, P < .001), without significant difference in NMD% (10.69 ± 3.19 vs 12.16 ± 3.69, P = .06). Plasma CT‐1 levels were not significantly different: 40.1 pg/mL (22.5‐102.1) vs 37.2 pg/mL (23.5‐67.2), P = .53.
Conclusion
Our results suggest worse ED in MINOCA than in INOCA patients, but demonstrated no difference in CT‐1 levels between patients with stable and unstable ischemic heart disease and normal coronary arteries.</description><identifier>ISSN: 0091-2751</identifier><identifier>EISSN: 1097-0096</identifier><identifier>DOI: 10.1002/jcu.22902</identifier><identifier>PMID: 32776332</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Acoustics ; Arteries ; brachial artery ; cardiotrophin‐1 ; Cardiovascular disease ; Cardiovascular diseases ; Coronary artery ; Coronary artery disease ; Coronary vessels ; endothelial dysfunction ; Endothelium ; Heart diseases ; Ischemia ; Life Sciences & Biomedicine ; Myocardial infarction ; Myocardial ischemia ; Nitroglycerin ; Radiology, Nuclear Medicine & Medical Imaging ; Science & Technology ; Technology ; Ultrasonic imaging ; Vasodilation</subject><ispartof>Journal of clinical ultrasound, 2021-05, Vol.49 (4), p.334-340</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals, LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>8</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000557283900001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c3532-bfa758fb8cad921d94c7413a9ea9a6ecea77fa168bd31c412d518f4aff73f66c3</citedby><cites>FETCH-LOGICAL-c3532-bfa758fb8cad921d94c7413a9ea9a6ecea77fa168bd31c412d518f4aff73f66c3</cites><orcidid>0000-0001-6084-0982</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcu.22902$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcu.22902$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,39263,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32776332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simsek, Ersin Cagri</creatorcontrib><creatorcontrib>Sari, Cenk</creatorcontrib><creatorcontrib>Kucukokur, Murat</creatorcontrib><creatorcontrib>Ekmekci, Cenk</creatorcontrib><creatorcontrib>Colak, Ayfer</creatorcontrib><creatorcontrib>Ozdogan, Oner</creatorcontrib><title>Endothelial dysfunction in patients with myocardial ischemia or infarction and nonobstructive coronary arteries</title><title>Journal of clinical ultrasound</title><addtitle>J CLIN ULTRASOUND</addtitle><addtitle>J Clin Ultrasound</addtitle><description>Purpose
The syndromes of myocardial infarction/myocardial ischemia with No Obstructive Coronary Artery Disease (MINOCA/INOCA) are seen more and more often. Endothelial dysfunction (ED) leading to ischemic events has been reported in many of these patients. We aimed to compare patients with MINOCA and INOCA regarding brachial artery flow‐mediated endothelium‐dependent vasodilation (flow‐mediated dilation [FMD]) and plasma concentration of cardiotrophin‐1 (CT‐1).
Methods
We included 42 patients with MINOCA and 38 patients with INOCA. Endothelial function was assessed by measuring FMD% and nitroglycerin‐mediated dilatation (NMD%) in the brachial artery. The plasma level of CT‐1 was determined by solid‐phase enzyme‐linked immunosorbent assay.
Results
FMD% was significantly lower in MINOCA than in INOCA patients (6.45 ± 2.65 vs 8.94 ± 3.32, P < .001), without significant difference in NMD% (10.69 ± 3.19 vs 12.16 ± 3.69, P = .06). Plasma CT‐1 levels were not significantly different: 40.1 pg/mL (22.5‐102.1) vs 37.2 pg/mL (23.5‐67.2), P = .53.
Conclusion
Our results suggest worse ED in MINOCA than in INOCA patients, but demonstrated no difference in CT‐1 levels between patients with stable and unstable ischemic heart disease and normal coronary arteries.</description><subject>Acoustics</subject><subject>Arteries</subject><subject>brachial artery</subject><subject>cardiotrophin‐1</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>endothelial dysfunction</subject><subject>Endothelium</subject><subject>Heart diseases</subject><subject>Ischemia</subject><subject>Life Sciences & Biomedicine</subject><subject>Myocardial infarction</subject><subject>Myocardial ischemia</subject><subject>Nitroglycerin</subject><subject>Radiology, Nuclear Medicine & Medical Imaging</subject><subject>Science & Technology</subject><subject>Technology</subject><subject>Ultrasonic imaging</subject><subject>Vasodilation</subject><issn>0091-2751</issn><issn>1097-0096</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><recordid>eNqNkU9rFTEUxYNY7LO68AvIgBtFps2fyWSylKFqS8GNXYc7mYSXx0zyTDIt79ub13l2IQiubgi_czn3HITeEXxJMKZXO71cUioxfYE2BEtRYyzbl2hTBqmp4OQcvU5phzFuOeev0DmjQrSM0Q0K134MeWsmB1M1HpJdvM4u-Mr5ag_ZGZ9T9ejytpoPQUMcj5xLemtmB1WIhbMQVwn4sfLBhyHluJSvB1PpEIOHeKggZhOdSW_QmYUpmbeneYHuv17_7L_Xdz--3fRf7mrNOKP1YEHwzg6dhlFSMspGi4YwkAYktEYbEMICabthZEQ3hI6cdLYBawWzbavZBfq47t3H8GsxKau5uDbTBN6EJSnaMNpxKTAp6Ie_0F1Yoi_uFOVYUoqJFIX6tFI6hpSisWof3VxOUwSrYwuqtKCeWijs-9PGZZjN-Ez-ib0A3Qo8miHYpEvM2jxjpSfOBe2YLC9MepfhmG8fFp-L9PP_Swt9daLdZA7_tqxu-_vV-2_D87R-</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Simsek, Ersin Cagri</creator><creator>Sari, Cenk</creator><creator>Kucukokur, Murat</creator><creator>Ekmekci, Cenk</creator><creator>Colak, Ayfer</creator><creator>Ozdogan, Oner</creator><general>John Wiley & Sons, Inc</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6084-0982</orcidid></search><sort><creationdate>202105</creationdate><title>Endothelial dysfunction in patients with myocardial ischemia or infarction and nonobstructive coronary arteries</title><author>Simsek, Ersin Cagri ; Sari, Cenk ; Kucukokur, Murat ; Ekmekci, Cenk ; Colak, Ayfer ; Ozdogan, Oner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-bfa758fb8cad921d94c7413a9ea9a6ecea77fa168bd31c412d518f4aff73f66c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acoustics</topic><topic>Arteries</topic><topic>brachial artery</topic><topic>cardiotrophin‐1</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Coronary artery</topic><topic>Coronary artery disease</topic><topic>Coronary vessels</topic><topic>endothelial dysfunction</topic><topic>Endothelium</topic><topic>Heart diseases</topic><topic>Ischemia</topic><topic>Life Sciences & Biomedicine</topic><topic>Myocardial infarction</topic><topic>Myocardial ischemia</topic><topic>Nitroglycerin</topic><topic>Radiology, Nuclear Medicine & Medical Imaging</topic><topic>Science & Technology</topic><topic>Technology</topic><topic>Ultrasonic imaging</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simsek, Ersin Cagri</creatorcontrib><creatorcontrib>Sari, Cenk</creatorcontrib><creatorcontrib>Kucukokur, Murat</creatorcontrib><creatorcontrib>Ekmekci, Cenk</creatorcontrib><creatorcontrib>Colak, Ayfer</creatorcontrib><creatorcontrib>Ozdogan, Oner</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical ultrasound</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simsek, Ersin Cagri</au><au>Sari, Cenk</au><au>Kucukokur, Murat</au><au>Ekmekci, Cenk</au><au>Colak, Ayfer</au><au>Ozdogan, Oner</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial dysfunction in patients with myocardial ischemia or infarction and nonobstructive coronary arteries</atitle><jtitle>Journal of clinical ultrasound</jtitle><stitle>J CLIN ULTRASOUND</stitle><addtitle>J Clin Ultrasound</addtitle><date>2021-05</date><risdate>2021</risdate><volume>49</volume><issue>4</issue><spage>334</spage><epage>340</epage><pages>334-340</pages><issn>0091-2751</issn><eissn>1097-0096</eissn><abstract>Purpose
The syndromes of myocardial infarction/myocardial ischemia with No Obstructive Coronary Artery Disease (MINOCA/INOCA) are seen more and more often. Endothelial dysfunction (ED) leading to ischemic events has been reported in many of these patients. We aimed to compare patients with MINOCA and INOCA regarding brachial artery flow‐mediated endothelium‐dependent vasodilation (flow‐mediated dilation [FMD]) and plasma concentration of cardiotrophin‐1 (CT‐1).
Methods
We included 42 patients with MINOCA and 38 patients with INOCA. Endothelial function was assessed by measuring FMD% and nitroglycerin‐mediated dilatation (NMD%) in the brachial artery. The plasma level of CT‐1 was determined by solid‐phase enzyme‐linked immunosorbent assay.
Results
FMD% was significantly lower in MINOCA than in INOCA patients (6.45 ± 2.65 vs 8.94 ± 3.32, P < .001), without significant difference in NMD% (10.69 ± 3.19 vs 12.16 ± 3.69, P = .06). Plasma CT‐1 levels were not significantly different: 40.1 pg/mL (22.5‐102.1) vs 37.2 pg/mL (23.5‐67.2), P = .53.
Conclusion
Our results suggest worse ED in MINOCA than in INOCA patients, but demonstrated no difference in CT‐1 levels between patients with stable and unstable ischemic heart disease and normal coronary arteries.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32776332</pmid><doi>10.1002/jcu.22902</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6084-0982</orcidid></addata></record> |
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| subjects | Acoustics Arteries brachial artery cardiotrophin‐1 Cardiovascular disease Cardiovascular diseases Coronary artery Coronary artery disease Coronary vessels endothelial dysfunction Endothelium Heart diseases Ischemia Life Sciences & Biomedicine Myocardial infarction Myocardial ischemia Nitroglycerin Radiology, Nuclear Medicine & Medical Imaging Science & Technology Technology Ultrasonic imaging Vasodilation |
| title | Endothelial dysfunction in patients with myocardial ischemia or infarction and nonobstructive coronary arteries |
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