Modulation of oxidative stress responses in the human retinal pigment epithelium following treatment with vitamin C

Oxidative stress (OS) in the retina plays an important role in the development and progression of age‐related macular degeneration (AMD). Our previous work has shown that OS can quantitatively regulate the expression of AP‐1 family genes in the retinal pigment epithelium (RPE). In this study, we sou...

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Veröffentlicht in:	Journal of cellular physiology 2011-08, Vol.226 (8), p.2025-2032
Hauptverfasser:	Yin, Jinggang, Thomas, Fridtjof, Lang, John C., Chaum, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 3 - genetics Activating Transcription Factor 3 - metabolism Antioxidants - pharmacology Ascorbic Acid - pharmacology Biomarkers - metabolism Cell Line Gene Expression Regulation - drug effects Humans Hydrogen Peroxide - adverse effects Oxidative Stress - drug effects Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism
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