The inhibitory effect of ginsan on TGF-β mediated fibrotic process

Transforming growth factor‐beta (TGF‐β) plays a central role in the development of fibrosis by stimulating extracellular matrix accumulation, and signals either directly or indirectly through types I, II, and III (TβRI, II, and III) TGF‐β receptor complexes. Ginsan, a polysaccharide extracted from P...

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Veröffentlicht in:	Journal of cellular physiology 2011-05, Vol.226 (5), p.1241-1247
Hauptverfasser:	Ahn, Ji-Yeon, Kim, Mi-Hyoung, Lim, Min-Jin, Park, Sarah, Lee, Sae-lo-oom, Yun, Yeon-Sook, Song, Jie-Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Bleomycin Collagen Type I - metabolism Disease Models, Animal Dose-Response Relationship, Drug Extracellular Signal-Regulated MAP Kinases - metabolism Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Fibronectins - metabolism Fibrosis Genes, Reporter Humans Lung - drug effects Lung - metabolism Lung - pathology Male Mice Mice, Inbred C57BL NIH 3T3 Cells Phosphorylation Polysaccharides - pharmacology Protein-Serine-Threonine Kinases - drug effects Protein-Serine-Threonine Kinases - metabolism Proteoglycans - drug effects Proteoglycans - metabolism Proto-Oncogene Proteins c-akt - metabolism Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control Receptors, Transforming Growth Factor beta - drug effects Receptors, Transforming Growth Factor beta - metabolism Recombinant Proteins - metabolism Signal Transduction - drug effects Smad2 Protein - genetics Smad2 Protein - metabolism Smad3 Protein - genetics Smad3 Protein - metabolism Time Factors Transfection Transforming Growth Factor beta1 - metabolism
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