Activation of HIF-1α in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway

Accumulation of HIF‐1α during normoxic conditions at high cell density has previously been shown to occur and can be used to stabilize HIF‐1α protein in the absence of a specific anaerobic chamber. However, the impact and origin of this pool of HIF‐1α, obtained under normoxia, has been underestimate...

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Veröffentlicht in:	Journal of cellular physiology 2009-01, Vol.218 (1), p.167-174
Hauptverfasser:	Dayan, Frédéric, Bilton, Rebecca L., Laferrière, Julie, Trottier, Eric, Roux, Danièle, Pouyssegur, Jacques, Mazure, Nathalie. M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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