All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes

One of the major characteristics of human skin photoaging induced by ultraviolet (UV) radiation is the dehydration of the skin. Water movement across plasma membrane occurs via diffusion through lipid bilayer and via aquaporins (AQPs). We find that UV induces aquaporin‐3 (AQP3) down‐regulation in hu...

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Veröffentlicht in:	Journal of cellular physiology 2008-05, Vol.215 (2), p.506-516
Hauptverfasser:	Cao, Cong, Wan, Shu, Jiang, Qin, Amaral, Ashley, Lu, Shan, Hu, Gang, Bi, Zhigang, Kouttab, Nicola, Chu, Wenming, Wan, Yinsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Antioxidants - pharmacology Aquaporin 3 - metabolism Cell Membrane Permeability - drug effects Cell Membrane Permeability - radiation effects Cell Movement - physiology Cells, Cultured Down-Regulation - drug effects Enzyme Inhibitors - pharmacology Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Genes, erbB-1 Humans Hydrogen Peroxide - pharmacology Keratinocytes - metabolism Keratinocytes - radiation effects Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Oxidants - pharmacology Time Factors Transcriptional Activation - physiology Tretinoin - pharmacology Ultraviolet Rays Water - metabolism Wound Healing - physiology
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