2,3,7,8-Tetrachlorodibenzo-p-dioxin: Examination of biochemical effects involved in the proliferation and differentiation of XB cells

XB, a cell line derived from a mouse teratoma, differentiates into stratified squamous epithelium when incubated with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD). To examine the possible biochemical mediators of this response, we compared the effects produced by TCDD to those elicited by other compou...

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Veröffentlicht in:	J. Cell. Physiol.; (United States) 1984-10, Vol.121 (1), p.143-151
Hauptverfasser:	Knutson, Joyce C., Poland, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques 560301 - Chemicals Metabolism & Toxicology- Cells- (-1987) ANIMAL CELLS Animals Arachidonic Acid Arachidonic Acids - metabolism AROMATICS AZINES BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOCHEMISTRY Biological and medical sciences BODY Cell Cycle - drug effects CELL DIFFERENTIATION Cell Differentiation - drug effects CELL PROLIFERATION Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases CHEMISTRY CHLORINATED AROMATIC HYDROCARBONS Cholera Toxin - pharmacology Cyclic AMP - metabolism DAYS LIVING RADIOISOTOPES Dioxins - pharmacology Epidermal Growth Factor - pharmacology HALOGENATED AROMATIC HYDROCARBONS HETEROCYCLIC COMPOUNDS ISOTOPES Keratins - biosynthesis LABELLED COMPOUNDS LIGHT NUCLEI Medical sciences METABOLISM Mice NUCLEI NUCLEOSIDES NUCLEOTIDES ODD-ODD NUCLEI ORGANIC CHLORINE COMPOUNDS ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS Phospholipids - metabolism PHOSPHORUS 32 PHOSPHORUS ISOTOPES Polychlorinated Dibenzodioxins - pharmacology PYRIMIDINES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIOISOTOPES RIBOSIDES SKIN Tetradecanoylphorbol Acetate - pharmacology THYMIDINE Toxicology TRITIUM COMPOUNDS TUMOR CELLS UPTAKE Various organic compounds
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