Mutants of chinese hamster cells deficient in thymidylate synthetase

Stable mutants of Chinese hamster V79 cells deficient in thymidylate synthetase (TS; E.C. 2.1.1.45) have been selected from cultures grown in medium supplemented with folinic acid, aminopterin, and thymidine (FAT). After chemical mutagenesis, the frequency of colonies resistant to the “FAT” medium i...

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Veröffentlicht in:	Journal of cellular physiology 1984-08, Vol.120 (2), p.109-116
Hauptverfasser:	Li, I-Chian, Chu, Ernest H. Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopterin - pharmacology Animal cells Animals Biological and medical sciences Biotechnology Cell cultures. Hybridization. Fusion Cell Line Cricetinae Cricetulus Culture Media Drug Resistance Establishment of new cell lines, improvement of cultural methods, mass cultures Eukaryotic cell cultures Fundamental and applied biological sciences. Psychology Leucovorin - pharmacology Lung Methods. Procedures. Technologies Methyltransferases - deficiency Molecular and cellular biology Mutation Thymidine - pharmacology Thymidylate Synthase - deficiency Thymidylate Synthase - genetics
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