Hyperoxia induces Egr-1 expression through activation of extracellular signal-regulated kinase 1/2 pathway

Early growth response gene (Egr‐1) is a stress response gene activated by various forms of stress and growth factor signaling. We report that supraphysiologic concentrations of O2 (hyperoxia) induced Egr‐1 mRNA and protein expression in cultured alveolar epithelial cells, as well as in mouse lung in...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular physiology 2003-08, Vol.196 (2), p.326-333
Hauptverfasser:	Jones, Nicole, Agani, Faton H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Early Growth Response Protein 1 Enzyme Activation Humans Hyperoxia - enzymology Hyperoxia - metabolism Immediate-Early Proteins Lung - metabolism Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases - metabolism p38 Mitogen-Activated Protein Kinases Phosphatidylinositol 3-Kinases - metabolism Receptor, Epidermal Growth Factor - metabolism RNA, Messenger - metabolism Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!