Induction of globin mRNA expression by interleukin-3 in a stem cell factor-dependent SV-40 T-antigen-immortalized multipotent hematopoietic cell line

Erythropoiesis requires the stepwise action on immature progenitors of several growth factors, including stem cell factor (SCF), interleukin 3 (IL‐3), and erythropoietin (Epo). Epo is required to sustain proliferation and survival of committed progenitors and might further modulate the level of expr...

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Veröffentlicht in:	Journal of cellular physiology 2003-04, Vol.195 (1), p.38-49
Hauptverfasser:	Cairns, Linda, Cirò, Marco, Minuzzo, Mario, Morlé, François, Starck, Joëlle, Ottolenghi, Sergio, Ronchi, Antonella
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - biosynthesis Antigens, Polyomavirus Transforming Cell Line, Transformed Enzyme Inhibitors - pharmacology Erythropoietin - pharmacology Gene Expression Regulation - drug effects Globins - biosynthesis Globins - genetics Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hemoglobins - biosynthesis Interleukin-3 - pharmacology Mice Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Multipotent Stem Cells - cytology Multipotent Stem Cells - drug effects Multipotent Stem Cells - metabolism p38 Mitogen-Activated Protein Kinases RNA, Messenger - biosynthesis Signal Transduction - drug effects Stem Cell Factor - pharmacology
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