APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population
Objective To analyze the relationship of Apolipoprotein E (APOE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene polymorphisms with coronary artery disease (CAD). Methods 1,129 CAD patients and 1,014 non‐CAD controls were included in the study, and relevant information...
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| Veröffentlicht in: | Journal of clinical laboratory analysis 2021-09, Vol.35 (9), p.e23925-n/a, Article 23925 |
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| description | Objective
To analyze the relationship of Apolipoprotein E (APOE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene polymorphisms with coronary artery disease (CAD).
Methods
1,129 CAD patients and 1,014 non‐CAD controls were included in the study, and relevant information and medical records were collected. The single‐nucleotide polymorphisms (SNPs) were analyzed, including rs429358, rs7412 in APOE gene and rs2306283, rs4149056 in SLCO1B1 gene.
Results
The CAD patients’ average age was 66.3 ± 10.7 years, while 65.5 ± 12.0 years in controls. The frequencies of APOE allele ɛ3, ɛ4, and ɛ2 were 83.01%, 10.08%, and 6.91% respectively. There were statistically significant differences in genotype ɛ3/ɛ4 (χ2 = 8.077, p = 0.005) in CAD patients compared with the controls. The SLCO1B1 genotype *1b/*1b and haplotype *1b showed the highest frequency in the study sample. Moreover, ε4 carriers had significantly lower HDL‐C, Apo‐A1 levels than ε3 carriers among CAD patients, while ε2 carriers showed lower LDL‐C, Apo‐B level, and higher Apo‐A1/Apo‐B level than ε3 and ε4 carriers. In controls, ε2 carriers showed lower LDL‐C and Apo‐B level, higher Apo‐A1, and Apo‐A1/Apo‐B level than ε4 carriers. Logistic regression analysis showed that high LDL‐C and Apo‐B level, low HDL‐C level, smoking, and the ε4 allele were risks for the presence of CAD.
Conclusions
APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD, but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene.
Apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) are involved in the regulation of lipid metabolism; however, the relationship between APOE and SLCO1B1 gene polymorphisms and coronary artery disease (CAD) has been controversial. APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD. This is the first systematic study of the association between CAD and APOE and SLCO1B1 gene polymorphisms in Hakka population. This study provides valuable information for the prediction of the risk of coronary heart disease. |
| doi_str_mv | 10.1002/jcla.23925 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_jcla_23925</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2555641716</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4485-2126432b539fb7ebf279961f5589357781698e8c61f55b38e6953918fb13fda23</originalsourceid><addsrcrecordid>eNqNkc2KFDEUhQtRnHZ04wNIwM2o9JifSirZCE0xOkrDuNB1SFXdTKe7OmmTKmV2gi_g3ifyNXwS0z826kJc3XDzncNJTlE8JPicYEyfL9venFOmKL9VTAhWckol5beLCZaymkpM2ElxL6UlxlgqIu4WJ6xkhDGOJ8WX2durC3QNHtD3byUyfQ89oDMmZf3j81dORf0EgbXQDgkFjxLEcY16t3FdQsZ3KLq0QsGiNsTgTbxBJg6QR-cSmATIZU0YhwVEj-qF85B3l2a1MmgTNmNvBhf8_eKONX2CB4d5Wrx_efGuvpzOr169rmfzaVuWkk8poaJktOFM2aaCxtJKKUEs51IxXlWSCCVBtrtVwyQIlVEibUOY7Qxlp8WLve9mbNbQteCHaHq9iW6dk-tgnP7zxruFvg4ftSyJLCXJBmcHgxg-jJAGvXaphb43HsKYNOWci5JURGT08V_oMozR5-dlSiic3cSWerqn2hhSimCPYQjW2271tlu96zbDj36Pf0R_lZkBuQc-QRNsah34Fo5Ybl9UCpeqzCdMajfsPr8Oox-y9Nn_SzNNDrTr4eYfmfWbej7bp_8Jh_DPbA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2569081366</pqid></control><display><type>article</type><title>APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Liu, Qinghua ; Wu, Heming ; Yu, Zhikang ; Huang, Qingyan ; Zhong, Zhixiong</creator><creatorcontrib>Liu, Qinghua ; Wu, Heming ; Yu, Zhikang ; Huang, Qingyan ; Zhong, Zhixiong</creatorcontrib><description>Objective
To analyze the relationship of Apolipoprotein E (APOE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene polymorphisms with coronary artery disease (CAD).
Methods
1,129 CAD patients and 1,014 non‐CAD controls were included in the study, and relevant information and medical records were collected. The single‐nucleotide polymorphisms (SNPs) were analyzed, including rs429358, rs7412 in APOE gene and rs2306283, rs4149056 in SLCO1B1 gene.
Results
The CAD patients’ average age was 66.3 ± 10.7 years, while 65.5 ± 12.0 years in controls. The frequencies of APOE allele ɛ3, ɛ4, and ɛ2 were 83.01%, 10.08%, and 6.91% respectively. There were statistically significant differences in genotype ɛ3/ɛ4 (χ2 = 8.077, p = 0.005) in CAD patients compared with the controls. The SLCO1B1 genotype *1b/*1b and haplotype *1b showed the highest frequency in the study sample. Moreover, ε4 carriers had significantly lower HDL‐C, Apo‐A1 levels than ε3 carriers among CAD patients, while ε2 carriers showed lower LDL‐C, Apo‐B level, and higher Apo‐A1/Apo‐B level than ε3 and ε4 carriers. In controls, ε2 carriers showed lower LDL‐C and Apo‐B level, higher Apo‐A1, and Apo‐A1/Apo‐B level than ε4 carriers. Logistic regression analysis showed that high LDL‐C and Apo‐B level, low HDL‐C level, smoking, and the ε4 allele were risks for the presence of CAD.
Conclusions
APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD, but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene.
Apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) are involved in the regulation of lipid metabolism; however, the relationship between APOE and SLCO1B1 gene polymorphisms and coronary artery disease (CAD) has been controversial. APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD. This is the first systematic study of the association between CAD and APOE and SLCO1B1 gene polymorphisms in Hakka population. This study provides valuable information for the prediction of the risk of coronary heart disease.</description><identifier>ISSN: 0887-8013</identifier><identifier>EISSN: 1098-2825</identifier><identifier>DOI: 10.1002/jcla.23925</identifier><identifier>PMID: 34313350</identifier><language>eng</language><publisher>HOBOKEN: Wiley</publisher><subject>Age ; Aged ; Alleles ; Angina pectoris ; Apolipoprotein E ; Apolipoproteins ; Apolipoproteins E - genetics ; Biomarkers - blood ; Cardiovascular disease ; Case-Control Studies ; China - epidemiology ; Cholesterol ; Coronary artery ; coronary artery disease ; Coronary Artery Disease - blood ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - genetics ; Coronary Artery Disease - pathology ; Coronary vessels ; Diabetes ; Female ; Follow-Up Studies ; Gene frequency ; Gene polymorphism ; Genes ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Hakka ; Haplotypes ; Heart diseases ; High density lipoprotein ; Hospitals ; Humans ; Hypertension ; Life Sciences & Biomedicine ; Lipids ; Lipids - blood ; Lipoproteins ; Liver-Specific Organic Anion Transporter 1 - genetics ; Low density lipoprotein ; Male ; Medical Laboratory Technology ; Medical records ; Metabolism ; Patients ; Polymorphism, Single Nucleotide ; Population ; Prognosis ; Retrospective Studies ; Risk Factors ; Science & Technology ; Serum lipids ; Single-nucleotide polymorphism ; solute carrier organic anion transporter family member 1B1 ; Statistical analysis ; Values</subject><ispartof>Journal of clinical laboratory analysis, 2021-09, Vol.35 (9), p.e23925-n/a, Article 23925</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC.</rights><rights>2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>14</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000679049400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4485-2126432b539fb7ebf279961f5589357781698e8c61f55b38e6953918fb13fda23</citedby><cites>FETCH-LOGICAL-c4485-2126432b539fb7ebf279961f5589357781698e8c61f55b38e6953918fb13fda23</cites><orcidid>0000-0002-1876-9585 ; 0000-0002-9997-5339</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418481/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8418481/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,1418,2115,11566,27928,27929,45578,45579,46056,46480,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34313350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Qinghua</creatorcontrib><creatorcontrib>Wu, Heming</creatorcontrib><creatorcontrib>Yu, Zhikang</creatorcontrib><creatorcontrib>Huang, Qingyan</creatorcontrib><creatorcontrib>Zhong, Zhixiong</creatorcontrib><title>APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population</title><title>Journal of clinical laboratory analysis</title><addtitle>J CLIN LAB ANAL</addtitle><addtitle>J Clin Lab Anal</addtitle><description>Objective
To analyze the relationship of Apolipoprotein E (APOE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene polymorphisms with coronary artery disease (CAD).
Methods
1,129 CAD patients and 1,014 non‐CAD controls were included in the study, and relevant information and medical records were collected. The single‐nucleotide polymorphisms (SNPs) were analyzed, including rs429358, rs7412 in APOE gene and rs2306283, rs4149056 in SLCO1B1 gene.
Results
The CAD patients’ average age was 66.3 ± 10.7 years, while 65.5 ± 12.0 years in controls. The frequencies of APOE allele ɛ3, ɛ4, and ɛ2 were 83.01%, 10.08%, and 6.91% respectively. There were statistically significant differences in genotype ɛ3/ɛ4 (χ2 = 8.077, p = 0.005) in CAD patients compared with the controls. The SLCO1B1 genotype *1b/*1b and haplotype *1b showed the highest frequency in the study sample. Moreover, ε4 carriers had significantly lower HDL‐C, Apo‐A1 levels than ε3 carriers among CAD patients, while ε2 carriers showed lower LDL‐C, Apo‐B level, and higher Apo‐A1/Apo‐B level than ε3 and ε4 carriers. In controls, ε2 carriers showed lower LDL‐C and Apo‐B level, higher Apo‐A1, and Apo‐A1/Apo‐B level than ε4 carriers. Logistic regression analysis showed that high LDL‐C and Apo‐B level, low HDL‐C level, smoking, and the ε4 allele were risks for the presence of CAD.
Conclusions
APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD, but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene.
Apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) are involved in the regulation of lipid metabolism; however, the relationship between APOE and SLCO1B1 gene polymorphisms and coronary artery disease (CAD) has been controversial. APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD. This is the first systematic study of the association between CAD and APOE and SLCO1B1 gene polymorphisms in Hakka population. This study provides valuable information for the prediction of the risk of coronary heart disease.</description><subject>Age</subject><subject>Aged</subject><subject>Alleles</subject><subject>Angina pectoris</subject><subject>Apolipoprotein E</subject><subject>Apolipoproteins</subject><subject>Apolipoproteins E - genetics</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Cholesterol</subject><subject>Coronary artery</subject><subject>coronary artery disease</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - pathology</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene frequency</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Hakka</subject><subject>Haplotypes</subject><subject>Heart diseases</subject><subject>High density lipoprotein</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Life Sciences & Biomedicine</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoproteins</subject><subject>Liver-Specific Organic Anion Transporter 1 - genetics</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medical Laboratory Technology</subject><subject>Medical records</subject><subject>Metabolism</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Science & Technology</subject><subject>Serum lipids</subject><subject>Single-nucleotide polymorphism</subject><subject>solute carrier organic anion transporter family member 1B1</subject><subject>Statistical analysis</subject><subject>Values</subject><issn>0887-8013</issn><issn>1098-2825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc2KFDEUhQtRnHZ04wNIwM2o9JifSirZCE0xOkrDuNB1SFXdTKe7OmmTKmV2gi_g3ifyNXwS0z826kJc3XDzncNJTlE8JPicYEyfL9venFOmKL9VTAhWckol5beLCZaymkpM2ElxL6UlxlgqIu4WJ6xkhDGOJ8WX2durC3QNHtD3byUyfQ89oDMmZf3j81dORf0EgbXQDgkFjxLEcY16t3FdQsZ3KLq0QsGiNsTgTbxBJg6QR-cSmATIZU0YhwVEj-qF85B3l2a1MmgTNmNvBhf8_eKONX2CB4d5Wrx_efGuvpzOr169rmfzaVuWkk8poaJktOFM2aaCxtJKKUEs51IxXlWSCCVBtrtVwyQIlVEibUOY7Qxlp8WLve9mbNbQteCHaHq9iW6dk-tgnP7zxruFvg4ftSyJLCXJBmcHgxg-jJAGvXaphb43HsKYNOWci5JURGT08V_oMozR5-dlSiic3cSWerqn2hhSimCPYQjW2271tlu96zbDj36Pf0R_lZkBuQc-QRNsah34Fo5Ybl9UCpeqzCdMajfsPr8Oox-y9Nn_SzNNDrTr4eYfmfWbej7bp_8Jh_DPbA</recordid><startdate>202109</startdate><enddate>202109</enddate><creator>Liu, Qinghua</creator><creator>Wu, Heming</creator><creator>Yu, Zhikang</creator><creator>Huang, Qingyan</creator><creator>Zhong, Zhixiong</creator><general>Wiley</general><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1876-9585</orcidid><orcidid>https://orcid.org/0000-0002-9997-5339</orcidid></search><sort><creationdate>202109</creationdate><title>APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population</title><author>Liu, Qinghua ; Wu, Heming ; Yu, Zhikang ; Huang, Qingyan ; Zhong, Zhixiong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4485-2126432b539fb7ebf279961f5589357781698e8c61f55b38e6953918fb13fda23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Age</topic><topic>Aged</topic><topic>Alleles</topic><topic>Angina pectoris</topic><topic>Apolipoprotein E</topic><topic>Apolipoproteins</topic><topic>Apolipoproteins E - genetics</topic><topic>Biomarkers - blood</topic><topic>Cardiovascular disease</topic><topic>Case-Control Studies</topic><topic>China - epidemiology</topic><topic>Cholesterol</topic><topic>Coronary artery</topic><topic>coronary artery disease</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - pathology</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene frequency</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Hakka</topic><topic>Haplotypes</topic><topic>Heart diseases</topic><topic>High density lipoprotein</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Life Sciences & Biomedicine</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipoproteins</topic><topic>Liver-Specific Organic Anion Transporter 1 - genetics</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Medical Laboratory Technology</topic><topic>Medical records</topic><topic>Metabolism</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Science & Technology</topic><topic>Serum lipids</topic><topic>Single-nucleotide polymorphism</topic><topic>solute carrier organic anion transporter family member 1B1</topic><topic>Statistical analysis</topic><topic>Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Qinghua</creatorcontrib><creatorcontrib>Wu, Heming</creatorcontrib><creatorcontrib>Yu, Zhikang</creatorcontrib><creatorcontrib>Huang, Qingyan</creatorcontrib><creatorcontrib>Zhong, Zhixiong</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical laboratory analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Qinghua</au><au>Wu, Heming</au><au>Yu, Zhikang</au><au>Huang, Qingyan</au><au>Zhong, Zhixiong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population</atitle><jtitle>Journal of clinical laboratory analysis</jtitle><stitle>J CLIN LAB ANAL</stitle><addtitle>J Clin Lab Anal</addtitle><date>2021-09</date><risdate>2021</risdate><volume>35</volume><issue>9</issue><spage>e23925</spage><epage>n/a</epage><pages>e23925-n/a</pages><artnum>23925</artnum><issn>0887-8013</issn><eissn>1098-2825</eissn><abstract>Objective
To analyze the relationship of Apolipoprotein E (APOE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene polymorphisms with coronary artery disease (CAD).
Methods
1,129 CAD patients and 1,014 non‐CAD controls were included in the study, and relevant information and medical records were collected. The single‐nucleotide polymorphisms (SNPs) were analyzed, including rs429358, rs7412 in APOE gene and rs2306283, rs4149056 in SLCO1B1 gene.
Results
The CAD patients’ average age was 66.3 ± 10.7 years, while 65.5 ± 12.0 years in controls. The frequencies of APOE allele ɛ3, ɛ4, and ɛ2 were 83.01%, 10.08%, and 6.91% respectively. There were statistically significant differences in genotype ɛ3/ɛ4 (χ2 = 8.077, p = 0.005) in CAD patients compared with the controls. The SLCO1B1 genotype *1b/*1b and haplotype *1b showed the highest frequency in the study sample. Moreover, ε4 carriers had significantly lower HDL‐C, Apo‐A1 levels than ε3 carriers among CAD patients, while ε2 carriers showed lower LDL‐C, Apo‐B level, and higher Apo‐A1/Apo‐B level than ε3 and ε4 carriers. In controls, ε2 carriers showed lower LDL‐C and Apo‐B level, higher Apo‐A1, and Apo‐A1/Apo‐B level than ε4 carriers. Logistic regression analysis showed that high LDL‐C and Apo‐B level, low HDL‐C level, smoking, and the ε4 allele were risks for the presence of CAD.
Conclusions
APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD, but not SNPs rs2306283 and rs4149056 of SLCO1B1 gene.
Apolipoprotein E (ApoE) and solute carrier organic anion transporter family member 1B1 (SLCO1B1) are involved in the regulation of lipid metabolism; however, the relationship between APOE and SLCO1B1 gene polymorphisms and coronary artery disease (CAD) has been controversial. APOE ε4 allele may be associated with susceptibility to CAD in southern Chinese Hakka population. It indicated that the APOE SNPs rs429358 and rs7412 are associated with CAD. This is the first systematic study of the association between CAD and APOE and SLCO1B1 gene polymorphisms in Hakka population. This study provides valuable information for the prediction of the risk of coronary heart disease.</abstract><cop>HOBOKEN</cop><pub>Wiley</pub><pmid>34313350</pmid><doi>10.1002/jcla.23925</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1876-9585</orcidid><orcidid>https://orcid.org/0000-0002-9997-5339</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0887-8013 |
| ispartof | Journal of clinical laboratory analysis, 2021-09, Vol.35 (9), p.e23925-n/a, Article 23925 |
| issn | 0887-8013 1098-2825 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jcla_23925 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central |
| subjects | Age Aged Alleles Angina pectoris Apolipoprotein E Apolipoproteins Apolipoproteins E - genetics Biomarkers - blood Cardiovascular disease Case-Control Studies China - epidemiology Cholesterol Coronary artery coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - epidemiology Coronary Artery Disease - genetics Coronary Artery Disease - pathology Coronary vessels Diabetes Female Follow-Up Studies Gene frequency Gene polymorphism Genes Genetic Predisposition to Disease Genotype Genotype & phenotype Hakka Haplotypes Heart diseases High density lipoprotein Hospitals Humans Hypertension Life Sciences & Biomedicine Lipids Lipids - blood Lipoproteins Liver-Specific Organic Anion Transporter 1 - genetics Low density lipoprotein Male Medical Laboratory Technology Medical records Metabolism Patients Polymorphism, Single Nucleotide Population Prognosis Retrospective Studies Risk Factors Science & Technology Serum lipids Single-nucleotide polymorphism solute carrier organic anion transporter family member 1B1 Statistical analysis Values |
| title | APOE gene ɛ4 allele (388C‐526C) effects on serum lipids and risk of coronary artery disease in southern Chinese Hakka population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T02%3A29%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=APOE%20gene%20%C9%9B4%20allele%20(388C%E2%80%90526C)%20effects%20on%20serum%20lipids%20and%20risk%20of%20coronary%20artery%20disease%20in%20southern%20Chinese%20Hakka%20population&rft.jtitle=Journal%20of%20clinical%20laboratory%20analysis&rft.au=Liu,%20Qinghua&rft.date=2021-09&rft.volume=35&rft.issue=9&rft.spage=e23925&rft.epage=n/a&rft.pages=e23925-n/a&rft.artnum=23925&rft.issn=0887-8013&rft.eissn=1098-2825&rft_id=info:doi/10.1002/jcla.23925&rft_dat=%3Cproquest_cross%3E2555641716%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2569081366&rft_id=info:pmid/34313350&rfr_iscdi=true |