Synthesis of Pyrazolo[3,4‐b]pyridine Derivatives and Their In‐Vitro and In‐Silico Antidiabetic Activities

ABSTRACT In the current study, new pyrazolo[3,4‐b]pyridine esters, hydrazides, and Schiff bases have been synthesized starting from 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐amine. The first step involved solvent‐free synthesis of pyrazolo[3,4‐b]pyridine‐6‐carboxylate derivatives (2a–d) with 55%–70% yield in t...

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Veröffentlicht in:	Journal of cellular biochemistry 2024-10, Vol.125 (10), p.e30646-n/a
Hauptverfasser:	Rafique, Iqra, Maqbool, Tahir, Javed, Muhammad Salman
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Amylases - antagonists & inhibitors alpha-Amylases - metabolism Animals antidiabetic activity Computer Simulation docking studies Humans Hydrazones - chemical synthesis Hydrazones - chemistry Hydrazones - pharmacology Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Molecular Docking Simulation Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology pyrazolo[3,4‐b]pyridine Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Structure-Activity Relationship α‐amylase
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