Suppression of c-Myc enhances p21 WAF1/CIP1 -mediated G1 cell cycle arrest through the modulation of ERK phosphorylation by ascochlorin

Numerous anti-cancer agents inhibit cell cycle progression via a p53-dependent mechanism; however, other genes such as the proto-oncogene c-Myc are promising targets for anticancer therapy. In the present study, we provide evidence that ascochlorin, an isoprenoid antibiotic, is a non-toxic anti-canc...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-02, Vol.119 (2), p.2036-2047
Hauptverfasser:	Jeong, Yun-Jeong, Hoe, Hyang-Sook, Cho, Hyun-Ji, Park, Kwan-Kyu, Kim, Dae-Dong, Kim, Cheorl-Ho, Magae, Junji, Kang, Dong Wook, Lee, Sang-Rae, Chang, Young-Chae
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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