Cellular distribution of gastric chief cell protein kinase C activity: Differential effects of diacylglycerol, phorbol esters, carbachol, and cholecystokinin

Stimulation of chief cells with carbachol or cholecystokinin (CCK) results in the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). Although IP3 increases cell calcium concentration, thereby stimulating pepsinogen secretion, the role of DAG and its target, protein kinase C (PKC),...

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Veröffentlicht in:	Journal of cellular biochemistry 1992-01, Vol.48 (1), p.107-113
Hauptverfasser:	Raffaniello, Robert D., Raufman, Jean-Piean
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carbachol - pharmacology Cell physiology Diglycerides - pharmacology Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Gastric Mucosa - cytology Gastric Mucosa - drug effects Gastric Mucosa - enzymology Guinea Pigs hormones Male Molecular and cellular biology pepsinogen secretion Pepsinogens - secretion Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Responses to growth factors, tumor promotors, other factors signal transduction Sincalide - pharmacology stomach Tetradecanoylphorbol Acetate - pharmacology translocation
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