Role of endogenous TGF-β family in myogenic differentiation of C2C12 cells

The present study evaluated endogenous activities and the role of BMP and transforming growth factor‐β (TGF‐β), representative members of the TGF‐β family, during myotube differentiation in C2C12 cells. Smad phosphorylation at the C‐terminal serines was monitored, since TGF‐β family members signal v...

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Veröffentlicht in:	Journal of cellular biochemistry 2011-02, Vol.112 (2), p.614-624
Hauptverfasser:	Furutani, Yuuma, Umemoto, Takenao, Murakami, Masaru, Matsui, Tohru, Funaba, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western BMP Bone Morphogenetic Protein 2 - pharmacology Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cell Differentiation - drug effects Cell Differentiation - genetics Cell Line Fluorescent Antibody Technique Mice Muscle Fibers, Skeletal - cytology Muscle Fibers, Skeletal - metabolism myotube differentiation Reverse Transcriptase Polymerase Chain Reaction TGF-β TGF-β family Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism
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