Retinoic acid-induced CD38 expression in HL-60 myeloblastic leukemia cells regulates cell differentiation or viability depending on expression levels

Retinoic acid‐induced expression of the CD38 ectoenzyme receptor in HL‐60 human myeloblastic leukemia cells is regulated by RARα and RXR, and enhanced or prevented cell differentiation depending on the level of expression per cell. RARα activation caused CD38 expression, as did RXR activation but no...

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Veröffentlicht in:	Journal of cellular biochemistry 2006-04, Vol.97 (6), p.1328-1338
Hauptverfasser:	Lamkin, Thomas J., Chin, Vivian, Varvayanis, Susi, Smith, James L., Sramkoski, R. Michael, Jacobberger, James W., Yen, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25‐dihydroxyvitamin D3 25-dihydroxyvitamin D3 ADP-ribosyl Cyclase 1 - genetics ADP-ribosyl Cyclase 1 - metabolism CD38 Cell Differentiation - drug effects Cell Survival - drug effects Fluorescent Antibody Technique Gene Expression Regulation HL-60 Cells Humans Leukemia, Myeloid, Acute - metabolism Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism retinoic acid Retinoic Acid Receptor alpha Retinoid X Receptors - genetics Retinoid X Receptors - metabolism Signal Transduction Time Factors Transfection Tretinoin - metabolism Tretinoin - pharmacology
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