Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer

Prostate specific membrane antigen (PSMA), is a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer as well as neovasculature of most of the solid tumors, but not in the vasculature of the normal tissues. This unique expression of PSMA makes it an important marker...

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Veröffentlicht in:	Journal of cellular biochemistry 2004-02, Vol.91 (3), p.528-539
Hauptverfasser:	Ghosh, Arundhati, Heston, Warren D.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Animals Antigens, Surface - genetics Antigens, Surface - physiology carboxypeptidase Contractile Proteins - physiology dileucine motif Dipeptides - metabolism Endocytosis - physiology Enhancer Elements, Genetic - genetics Filamins folate hydrolase Folic Acid - metabolism folylpoly-γ-glutamate Gene Expression Regulation, Neoplastic Glutamate Carboxypeptidase II - genetics Glutamate Carboxypeptidase II - physiology Humans internalization Male Mice Microfilament Proteins - physiology Models, Biological prostate specific membrane antigen Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - physiopathology Receptors, Androgen - metabolism
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