Non-apoptogenic killing of hela cervical carcinoma cells after short exposure to the alkylating agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)

We examined the action of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine (MNNG) on HeLa cells and compared it with that of cisplatin (CP). MNNG directly killed a substantial number of cells within 1 hour and resulted in strong DNA‐damage as evidenced by Comet measurements. Despite appearance of DNA lesions, p...

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