Combined vascular targeted imaging and therapy: A paradigm for personalized treatment
In order to be successful in personalizing treatment, methods for selecting patients as well as good surrogate biomarkers for monitoring the effects of treatment are required in addition to development of an efficacious targeted therapy. We have developed a polymerized nanoparticle platform technolo...
Gespeichert in:
| Veröffentlicht in: | Journal of cellular biochemistry 2002, Vol.87 (S39), p.65-71 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 71 |
|---|---|
| container_issue | S39 |
| container_start_page | 65 |
| container_title | Journal of cellular biochemistry |
| container_volume | 87 |
| creator | Li, King C.P. Guccione, Samira Bednarski, Mark D. |
| description | In order to be successful in personalizing treatment, methods for selecting patients as well as good surrogate biomarkers for monitoring the effects of treatment are required in addition to development of an efficacious targeted therapy. We have developed a polymerized nanoparticle platform technology that will allow us to put different targeting moieties on the surface of the particles in addition to loading the particles with different contrast and therapeutic agents. We have proven that these nanoparticles can be targeted to endothelial receptors and different payloads of contrast and therapeutic agents have been delivered to target cells with high target to background ratios. Using this combined vascular targeted imaging and therapy approach, we are optimistic that personalized treatment regimens can be developed for different disease processes such as cancer, inflammation, and ischemia. J. Cell. Biochem. Suppl. 39: 65–71, 2002. © 2002 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jcb.10401 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_jcb_10401</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JCB10401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3591-8a9275d330e05c62f5dd01d53f9786fe5c736f220d66aceb1911d61eeab605693</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0EoqWw4AeQtyxCx3bsNOwgghZUARJUXVpO7ISUvGSnQPl6AimwYjWj0blXo4PQMYEzAkDHqyTuFh_IDhoSCAPPF76_i4YQMPAoI3SADpxbAUAYMrqPBoRyTgX4Q7SI6jLOK6Pxq3LJulAWt8pmpu0ueamyvMqwqjRun41VzeYcX-BGWaXzrMRpbXFjrKsrVeQfXaC1RrWlqdpDtJeqwpmj7RyhxfXVUzTz5vfTm-hi7iWMh8SbqJAGXDMGBngiaMq1BqI5S8NgIlLDk4CJlFLQQqjExCQkRAtijIoFcBGyETrtexNbO2dNKhvbfW03koD8UiM7NfJbTcee9Gyzjkuj_8itiw4Y98BbXpjN_03yNrr8qfT6RO5a8_6bUPZFioAFXC7vpvKRsaV4mM8kYZ_fhXx7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Combined vascular targeted imaging and therapy: A paradigm for personalized treatment</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Li, King C.P. ; Guccione, Samira ; Bednarski, Mark D.</creator><creatorcontrib>Li, King C.P. ; Guccione, Samira ; Bednarski, Mark D.</creatorcontrib><description>In order to be successful in personalizing treatment, methods for selecting patients as well as good surrogate biomarkers for monitoring the effects of treatment are required in addition to development of an efficacious targeted therapy. We have developed a polymerized nanoparticle platform technology that will allow us to put different targeting moieties on the surface of the particles in addition to loading the particles with different contrast and therapeutic agents. We have proven that these nanoparticles can be targeted to endothelial receptors and different payloads of contrast and therapeutic agents have been delivered to target cells with high target to background ratios. Using this combined vascular targeted imaging and therapy approach, we are optimistic that personalized treatment regimens can be developed for different disease processes such as cancer, inflammation, and ischemia. J. Cell. Biochem. Suppl. 39: 65–71, 2002. © 2002 Wiley‐Liss, Inc.</description><identifier>ISSN: 0730-2312</identifier><identifier>ISSN: 0733-1959</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.10401</identifier><identifier>PMID: 12552604</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>angiogenesis ; Animals ; Contrast Media - administration & dosage ; diagnosis ; Diagnostic Imaging - methods ; Disease Models, Animal ; Endothelium, Vascular - metabolism ; Genetic Therapy ; imaging ; Integrins - metabolism ; Mice ; Nanotechnology ; Neoplasms, Experimental - blood supply ; Neoplasms, Experimental - diagnosis ; Neoplasms, Experimental - pathology ; Neoplasms, Experimental - therapy ; Polymers ; treatment</subject><ispartof>Journal of cellular biochemistry, 2002, Vol.87 (S39), p.65-71</ispartof><rights>Copyright © 2002 Wiley‐Liss, Inc.</rights><rights>Copyright 2002 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3591-8a9275d330e05c62f5dd01d53f9786fe5c736f220d66aceb1911d61eeab605693</citedby><cites>FETCH-LOGICAL-c3591-8a9275d330e05c62f5dd01d53f9786fe5c736f220d66aceb1911d61eeab605693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.10401$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.10401$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12552604$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, King C.P.</creatorcontrib><creatorcontrib>Guccione, Samira</creatorcontrib><creatorcontrib>Bednarski, Mark D.</creatorcontrib><title>Combined vascular targeted imaging and therapy: A paradigm for personalized treatment</title><title>Journal of cellular biochemistry</title><addtitle>J. Cell. Biochem</addtitle><description>In order to be successful in personalizing treatment, methods for selecting patients as well as good surrogate biomarkers for monitoring the effects of treatment are required in addition to development of an efficacious targeted therapy. We have developed a polymerized nanoparticle platform technology that will allow us to put different targeting moieties on the surface of the particles in addition to loading the particles with different contrast and therapeutic agents. We have proven that these nanoparticles can be targeted to endothelial receptors and different payloads of contrast and therapeutic agents have been delivered to target cells with high target to background ratios. Using this combined vascular targeted imaging and therapy approach, we are optimistic that personalized treatment regimens can be developed for different disease processes such as cancer, inflammation, and ischemia. J. Cell. Biochem. Suppl. 39: 65–71, 2002. © 2002 Wiley‐Liss, Inc.</description><subject>angiogenesis</subject><subject>Animals</subject><subject>Contrast Media - administration & dosage</subject><subject>diagnosis</subject><subject>Diagnostic Imaging - methods</subject><subject>Disease Models, Animal</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Genetic Therapy</subject><subject>imaging</subject><subject>Integrins - metabolism</subject><subject>Mice</subject><subject>Nanotechnology</subject><subject>Neoplasms, Experimental - blood supply</subject><subject>Neoplasms, Experimental - diagnosis</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Neoplasms, Experimental - therapy</subject><subject>Polymers</subject><subject>treatment</subject><issn>0730-2312</issn><issn>0733-1959</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0EoqWw4AeQtyxCx3bsNOwgghZUARJUXVpO7ISUvGSnQPl6AimwYjWj0blXo4PQMYEzAkDHqyTuFh_IDhoSCAPPF76_i4YQMPAoI3SADpxbAUAYMrqPBoRyTgX4Q7SI6jLOK6Pxq3LJulAWt8pmpu0ueamyvMqwqjRun41VzeYcX-BGWaXzrMRpbXFjrKsrVeQfXaC1RrWlqdpDtJeqwpmj7RyhxfXVUzTz5vfTm-hi7iWMh8SbqJAGXDMGBngiaMq1BqI5S8NgIlLDk4CJlFLQQqjExCQkRAtijIoFcBGyETrtexNbO2dNKhvbfW03koD8UiM7NfJbTcee9Gyzjkuj_8itiw4Y98BbXpjN_03yNrr8qfT6RO5a8_6bUPZFioAFXC7vpvKRsaV4mM8kYZ_fhXx7</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Li, King C.P.</creator><creator>Guccione, Samira</creator><creator>Bednarski, Mark D.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2002</creationdate><title>Combined vascular targeted imaging and therapy: A paradigm for personalized treatment</title><author>Li, King C.P. ; Guccione, Samira ; Bednarski, Mark D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3591-8a9275d330e05c62f5dd01d53f9786fe5c736f220d66aceb1911d61eeab605693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>angiogenesis</topic><topic>Animals</topic><topic>Contrast Media - administration & dosage</topic><topic>diagnosis</topic><topic>Diagnostic Imaging - methods</topic><topic>Disease Models, Animal</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Genetic Therapy</topic><topic>imaging</topic><topic>Integrins - metabolism</topic><topic>Mice</topic><topic>Nanotechnology</topic><topic>Neoplasms, Experimental - blood supply</topic><topic>Neoplasms, Experimental - diagnosis</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Neoplasms, Experimental - therapy</topic><topic>Polymers</topic><topic>treatment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, King C.P.</creatorcontrib><creatorcontrib>Guccione, Samira</creatorcontrib><creatorcontrib>Bednarski, Mark D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, King C.P.</au><au>Guccione, Samira</au><au>Bednarski, Mark D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined vascular targeted imaging and therapy: A paradigm for personalized treatment</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J. Cell. Biochem</addtitle><date>2002</date><risdate>2002</risdate><volume>87</volume><issue>S39</issue><spage>65</spage><epage>71</epage><pages>65-71</pages><issn>0730-2312</issn><issn>0733-1959</issn><eissn>1097-4644</eissn><abstract>In order to be successful in personalizing treatment, methods for selecting patients as well as good surrogate biomarkers for monitoring the effects of treatment are required in addition to development of an efficacious targeted therapy. We have developed a polymerized nanoparticle platform technology that will allow us to put different targeting moieties on the surface of the particles in addition to loading the particles with different contrast and therapeutic agents. We have proven that these nanoparticles can be targeted to endothelial receptors and different payloads of contrast and therapeutic agents have been delivered to target cells with high target to background ratios. Using this combined vascular targeted imaging and therapy approach, we are optimistic that personalized treatment regimens can be developed for different disease processes such as cancer, inflammation, and ischemia. J. Cell. Biochem. Suppl. 39: 65–71, 2002. © 2002 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>12552604</pmid><doi>10.1002/jcb.10401</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0730-2312 |
| ispartof | Journal of cellular biochemistry, 2002, Vol.87 (S39), p.65-71 |
| issn | 0730-2312 0733-1959 1097-4644 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_jcb_10401 |
| source | MEDLINE; Wiley Journals |
| subjects | angiogenesis Animals Contrast Media - administration & dosage diagnosis Diagnostic Imaging - methods Disease Models, Animal Endothelium, Vascular - metabolism Genetic Therapy imaging Integrins - metabolism Mice Nanotechnology Neoplasms, Experimental - blood supply Neoplasms, Experimental - diagnosis Neoplasms, Experimental - pathology Neoplasms, Experimental - therapy Polymers treatment |
| title | Combined vascular targeted imaging and therapy: A paradigm for personalized treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T01%3A38%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wiley_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Combined%20vascular%20targeted%20imaging%20and%20therapy:%20A%20paradigm%20for%20personalized%20treatment&rft.jtitle=Journal%20of%20cellular%20biochemistry&rft.au=Li,%20King%20C.P.&rft.date=2002&rft.volume=87&rft.issue=S39&rft.spage=65&rft.epage=71&rft.pages=65-71&rft.issn=0730-2312&rft.eissn=1097-4644&rft_id=info:doi/10.1002/jcb.10401&rft_dat=%3Cwiley_cross%3EJCB10401%3C/wiley_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/12552604&rfr_iscdi=true |