Plasma concentrations of pituitary hormones in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated male rats

Experiments were conducted to test the hypothesis that acute TCDD toxicity is associated with pituitary hypofunction. Sexually mature male Sprague‐Dawley rats were given graded doses of TCDD (0–100 μg/kg) and evaluated 7 days later. Despite pronounced hypophagia and body weight loss, plasma concentr...

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Veröffentlicht in:	Journal of biochemical toxicology 1989, Vol.4 (3), p.165-172
Hauptverfasser:	Moore, Robert W., Parsons, Jonathan A., Bookstaff, Robert C., Peterson, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin 8-Tetrachlorodibenzo-p-dioxin Adrenocorticotropic Hormone Adrenocorticotropic Hormone - blood Animals Dioxins - toxicity Dose-Response Relationship, Drug Follicle Stimulating Hormone - blood Follicle-stimulating Hormone Growth Hormone Luteinizing Hormone Male Organ Size - drug effects Pituitary Hormones Pituitary Hormones - blood Polychlorinated Dibenzodioxins - toxicity Prolactin Prolactin - blood Prostate - drug effects Radioimmunoassay Rats Rats, Inbred Strains Time Factors
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