Melatonin inhibits the contractile effect of vanadate in the isolated pulmonary arterial rings of rats: Possible role of hydrogen peroxide

The effect and possible mechanism of action of vanadate on the isolated pulmonary arterial rings of normal rats were studied. Pulmonary arterial rings contracted in response to vanadate (0.1–1 mM) in a concentration‐dependent manner. Preincubation of the pulmonary arterial rings with 1 mM melatonin...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2002-01, Vol.16 (6), p.273-278
Hauptverfasser:	Nagi, Mahmoud N., Mansour, Mahmoud A., Al-shabanah, Othman A., El-Kashef, Hassan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Interactions Glucose - metabolism Glucose Oxidase - metabolism Hydrogen Peroxide Hydrogen Peroxide - metabolism Hydrogen Peroxide - pharmacology In Vitro Techniques Kinetics Melatonin Melatonin - pharmacology Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology NAD - metabolism Oxidation-Reduction Pulmonary Arterial Rings Pulmonary Artery - drug effects Pulmonary Artery - physiology Rats Rats, Wistar Vanadate Vanadates - antagonists & inhibitors Vanadates - pharmacology Xanthine Oxidase Xanthine Oxidase - metabolism
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