Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9-oxo-10,11-dehydroageraphorone, isolated from Eupatorium adenophorum
Eupatorium adenophorum leaves cause hepatotoxicity and cholestasis in rats. The hepatotoxicant has been characterized as 9‐oxo‐10,11‐dehydroageraphorone (ODA), a cadinene sesquiterpene. Oral administration of ODA, mixed in feed to rats, caused jaundice in 24 h. The liver of the intoxicated animals h...
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| Veröffentlicht in: | Journal of biochemical and molecular toxicology 2001, Vol.15 (5), p.279-286 |
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| container_title | Journal of biochemical and molecular toxicology |
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| creator | Bhardwaj, Renu Singh, Ajay Sharma, Om P. Dawra, Rajinder K. Kurade, Nitin P. Mahato, Shashi B. |
| description | Eupatorium adenophorum leaves cause hepatotoxicity and cholestasis in rats. The hepatotoxicant has been characterized as 9‐oxo‐10,11‐dehydroageraphorone (ODA), a cadinene sesquiterpene. Oral administration of ODA, mixed in feed to rats, caused jaundice in 24 h. The liver of the intoxicated animals had focal areas of hepatocellular necrosis, proliferation, and dilation of bile ducts with degenerative changes in the lining epithelium. There was marked increase in the conjugated form of plasma bilirubin and in the activities of the enzymes glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, lactate dehydrogenase, γ‐glutamyltranspeptidase, glutamate dehydrogenase, and 5′‐nucleotidase. The histopathological lesions in liver and biochemical profile of marker enzymes show that ODA induced hepatotoxicity and cholestasis in rats. This is the first report on the toxicity of a cadinene sesquiterpene in rats. © 2001 John Wiley & Sons, Inc. J Biochem Mol Toxicol 15:279–286, 2001 |
| doi_str_mv | 10.1002/jbt.10001 |
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The hepatotoxicant has been characterized as 9‐oxo‐10,11‐dehydroageraphorone (ODA), a cadinene sesquiterpene. Oral administration of ODA, mixed in feed to rats, caused jaundice in 24 h. The liver of the intoxicated animals had focal areas of hepatocellular necrosis, proliferation, and dilation of bile ducts with degenerative changes in the lining epithelium. There was marked increase in the conjugated form of plasma bilirubin and in the activities of the enzymes glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, lactate dehydrogenase, γ‐glutamyltranspeptidase, glutamate dehydrogenase, and 5′‐nucleotidase. The histopathological lesions in liver and biochemical profile of marker enzymes show that ODA induced hepatotoxicity and cholestasis in rats. This is the first report on the toxicity of a cadinene sesquiterpene in rats. © 2001 John Wiley & Sons, Inc. J Biochem Mol Toxicol 15:279–286, 2001</description><identifier>ISSN: 1095-6670</identifier><identifier>EISSN: 1099-0461</identifier><identifier>DOI: 10.1002/jbt.10001</identifier><identifier>PMID: 11835625</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>11-Dehydroageraphorone ; 9-oxo-10 ; 9‐oxo‐10,11‐Dehydroageraphorone ; Animals ; Asteraceae - chemistry ; Cholestasis - chemically induced ; Chromatography, High Pressure Liquid ; Chromatography, Thin Layer ; Eupatorium adenophorum ; Hepatotoxicant ; Hepatotoxicity ; Liver - drug effects ; Magnetic Resonance Spectroscopy ; Male ; Plant Leaves - chemistry ; Rats ; Rats, Wistar ; Sesquiterpene ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - toxicity ; Spectrophotometry, Ultraviolet</subject><ispartof>Journal of biochemical and molecular toxicology, 2001, Vol.15 (5), p.279-286</ispartof><rights>Copyright © 2001 John Wiley & Sons, Inc.</rights><rights>Copyright 2001 John Wiley & Sons, Inc. J Biochem Mol Toxicol 15:279–286, 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3401-d0b87f6c258c8c50d86a92cfc4b28a48f7aa4a55255f650e4076bf5f91331a723</citedby><cites>FETCH-LOGICAL-c3401-d0b87f6c258c8c50d86a92cfc4b28a48f7aa4a55255f650e4076bf5f91331a723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbt.10001$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbt.10001$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11835625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhardwaj, Renu</creatorcontrib><creatorcontrib>Singh, Ajay</creatorcontrib><creatorcontrib>Sharma, Om P.</creatorcontrib><creatorcontrib>Dawra, Rajinder K.</creatorcontrib><creatorcontrib>Kurade, Nitin P.</creatorcontrib><creatorcontrib>Mahato, Shashi B.</creatorcontrib><title>Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9-oxo-10,11-dehydroageraphorone, isolated from Eupatorium adenophorum</title><title>Journal of biochemical and molecular toxicology</title><addtitle>J. Biochem. Mol. Toxicol</addtitle><description>Eupatorium adenophorum leaves cause hepatotoxicity and cholestasis in rats. The hepatotoxicant has been characterized as 9‐oxo‐10,11‐dehydroageraphorone (ODA), a cadinene sesquiterpene. Oral administration of ODA, mixed in feed to rats, caused jaundice in 24 h. The liver of the intoxicated animals had focal areas of hepatocellular necrosis, proliferation, and dilation of bile ducts with degenerative changes in the lining epithelium. There was marked increase in the conjugated form of plasma bilirubin and in the activities of the enzymes glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, lactate dehydrogenase, γ‐glutamyltranspeptidase, glutamate dehydrogenase, and 5′‐nucleotidase. The histopathological lesions in liver and biochemical profile of marker enzymes show that ODA induced hepatotoxicity and cholestasis in rats. This is the first report on the toxicity of a cadinene sesquiterpene in rats. © 2001 John Wiley & Sons, Inc. J Biochem Mol Toxicol 15:279–286, 2001</description><subject>11-Dehydroageraphorone</subject><subject>9-oxo-10</subject><subject>9‐oxo‐10,11‐Dehydroageraphorone</subject><subject>Animals</subject><subject>Asteraceae - chemistry</subject><subject>Cholestasis - chemically induced</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Chromatography, Thin Layer</subject><subject>Eupatorium adenophorum</subject><subject>Hepatotoxicant</subject><subject>Hepatotoxicity</subject><subject>Liver - drug effects</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Plant Leaves - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sesquiterpene</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - toxicity</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>1095-6670</issn><issn>1099-0461</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1O3DAUhS1UxP-iL1B5W4mAncROsmxHlB8hKHQqltaNc90xnYyD7aiTV-hTkzBQVl3ds_jOd6VDyEfOTjhj6eljHafA-BbZ46yqEpZL_uEli0TKgu2S_RAeR0JUhdghu5yXmZCp2CN_L7CD6KJbW23jQGHVUL1wSwwRgg3UrqiHON2m19jQeqBxgTRgeOptRN_hCo9plbi1Szg75jxpcDE03sEv9NAtnHcTYINbQhz7xruWnvXTT2_7lkKDKzdhfXtItg0sAx693gPy89vZfHaRXN-eX86-XCc6y9noZ3VZGKlTUepSC9aUEqpUG53XaQl5aQqAHIRIhTBSMMxZIWsjTMWzjEORZgfk88arvQvBo1Gdty34QXGmpj3VuKd62XNkP23Yrq9bbN7J1wFH4HQD_LFLHP5vUldf52_KZNOwIeL6XwP8byWLrBDq4eZc3dzdz8T8-w81z54B_rqQzQ</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Bhardwaj, Renu</creator><creator>Singh, Ajay</creator><creator>Sharma, Om P.</creator><creator>Dawra, Rajinder K.</creator><creator>Kurade, Nitin P.</creator><creator>Mahato, Shashi B.</creator><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2001</creationdate><title>Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9-oxo-10,11-dehydroageraphorone, isolated from Eupatorium adenophorum</title><author>Bhardwaj, Renu ; Singh, Ajay ; Sharma, Om P. ; Dawra, Rajinder K. ; Kurade, Nitin P. ; Mahato, Shashi B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3401-d0b87f6c258c8c50d86a92cfc4b28a48f7aa4a55255f650e4076bf5f91331a723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>11-Dehydroageraphorone</topic><topic>9-oxo-10</topic><topic>9‐oxo‐10,11‐Dehydroageraphorone</topic><topic>Animals</topic><topic>Asteraceae - chemistry</topic><topic>Cholestasis - chemically induced</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Chromatography, Thin Layer</topic><topic>Eupatorium adenophorum</topic><topic>Hepatotoxicant</topic><topic>Hepatotoxicity</topic><topic>Liver - drug effects</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Plant Leaves - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sesquiterpene</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - toxicity</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhardwaj, Renu</creatorcontrib><creatorcontrib>Singh, Ajay</creatorcontrib><creatorcontrib>Sharma, Om P.</creatorcontrib><creatorcontrib>Dawra, Rajinder K.</creatorcontrib><creatorcontrib>Kurade, Nitin P.</creatorcontrib><creatorcontrib>Mahato, Shashi B.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of biochemical and molecular toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhardwaj, Renu</au><au>Singh, Ajay</au><au>Sharma, Om P.</au><au>Dawra, Rajinder K.</au><au>Kurade, Nitin P.</au><au>Mahato, Shashi B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9-oxo-10,11-dehydroageraphorone, isolated from Eupatorium adenophorum</atitle><jtitle>Journal of biochemical and molecular toxicology</jtitle><addtitle>J. Biochem. Mol. Toxicol</addtitle><date>2001</date><risdate>2001</risdate><volume>15</volume><issue>5</issue><spage>279</spage><epage>286</epage><pages>279-286</pages><issn>1095-6670</issn><eissn>1099-0461</eissn><abstract>Eupatorium adenophorum leaves cause hepatotoxicity and cholestasis in rats. The hepatotoxicant has been characterized as 9‐oxo‐10,11‐dehydroageraphorone (ODA), a cadinene sesquiterpene. Oral administration of ODA, mixed in feed to rats, caused jaundice in 24 h. The liver of the intoxicated animals had focal areas of hepatocellular necrosis, proliferation, and dilation of bile ducts with degenerative changes in the lining epithelium. There was marked increase in the conjugated form of plasma bilirubin and in the activities of the enzymes glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, alkaline phosphatase, lactate dehydrogenase, γ‐glutamyltranspeptidase, glutamate dehydrogenase, and 5′‐nucleotidase. The histopathological lesions in liver and biochemical profile of marker enzymes show that ODA induced hepatotoxicity and cholestasis in rats. This is the first report on the toxicity of a cadinene sesquiterpene in rats. © 2001 John Wiley & Sons, Inc. J Biochem Mol Toxicol 15:279–286, 2001</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>11835625</pmid><doi>10.1002/jbt.10001</doi><tpages>8</tpages></addata></record> |
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| subjects | 11-Dehydroageraphorone 9-oxo-10 9‐oxo‐10,11‐Dehydroageraphorone Animals Asteraceae - chemistry Cholestasis - chemically induced Chromatography, High Pressure Liquid Chromatography, Thin Layer Eupatorium adenophorum Hepatotoxicant Hepatotoxicity Liver - drug effects Magnetic Resonance Spectroscopy Male Plant Leaves - chemistry Rats Rats, Wistar Sesquiterpene Sesquiterpenes - isolation & purification Sesquiterpenes - toxicity Spectrophotometry, Ultraviolet |
| title | Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9-oxo-10,11-dehydroageraphorone, isolated from Eupatorium adenophorum |
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