Toxic and genotoxic action of electric-arc welding fumes on cultured mammalian cells
Welding fumes generated by manual metal arc welding (MMAW) with an automatic welding machine were extracted with water and both the soluble and insoluble fractions were investigated for mitotic delay and for sister chromatid exchange (SCE) induction in cultured Chinese hamster Iung (Don) cells. Five...
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| Veröffentlicht in: | Journal of applied toxicology 1986-10, Vol.6 (5), p.357-362 |
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| creator | Baker, R. S. U. Arlauskas, A. Tandon, R. K. Crisp, P. T. Ellis, J. |
| description | Welding fumes generated by manual metal arc welding (MMAW) with an automatic welding machine were extracted with water and both the soluble and insoluble fractions were investigated for mitotic delay and for sister chromatid exchange (SCE) induction in cultured Chinese hamster Iung (Don) cells. Five flux‐coated electrodes of varying composition were chosen as representative of those available. In general, watersoluble and water‐insoluble fractions induced SCE in proportion to their chromium (VI) content, and any contribution from chromium(III), fluorides, nickel, manganese or other fume constituents was minor. However, mitotic delay could not be explained in terms of the chromium(VI) concentration alone. This indicated that other components of both the soluble and insoluble fractions of the fumes were capable of inducing mitotic delay. The activity of insoluble fume fractions, either in mitotic delay‐ or in SCE‐induction, was markedly less than than that of soluble fractions. This was presumably because of the lower, though still significant, bioavailability of ‘insoluble’ components of the fume particles. |
| doi_str_mv | 10.1002/jat.2550060510 |
| format | Article |
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S. U. ; Arlauskas, A. ; Tandon, R. K. ; Crisp, P. T. ; Ellis, J.</creator><creatorcontrib>Baker, R. S. U. ; Arlauskas, A. ; Tandon, R. K. ; Crisp, P. T. ; Ellis, J.</creatorcontrib><description>Welding fumes generated by manual metal arc welding (MMAW) with an automatic welding machine were extracted with water and both the soluble and insoluble fractions were investigated for mitotic delay and for sister chromatid exchange (SCE) induction in cultured Chinese hamster Iung (Don) cells. Five flux‐coated electrodes of varying composition were chosen as representative of those available. In general, watersoluble and water‐insoluble fractions induced SCE in proportion to their chromium (VI) content, and any contribution from chromium(III), fluorides, nickel, manganese or other fume constituents was minor. However, mitotic delay could not be explained in terms of the chromium(VI) concentration alone. This indicated that other components of both the soluble and insoluble fractions of the fumes were capable of inducing mitotic delay. The activity of insoluble fume fractions, either in mitotic delay‐ or in SCE‐induction, was markedly less than than that of soluble fractions. This was presumably because of the lower, though still significant, bioavailability of ‘insoluble’ components of the fume particles.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550060510</identifier><identifier>PMID: 3772012</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Air Pollutants, Occupational - analysis ; Air Pollutants, Occupational - toxicity ; Animals ; Biological and medical sciences ; Cells, Cultured ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chinese hamster lung cells ; Chromium - analysis ; chromium(III) ; chromium(VI) ; Cricetinae ; Cricetulus ; Fluorides - analysis ; in vitro ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; Lung - drug effects ; Medical sciences ; metals ; Mitosis - drug effects ; mitotic delay ; Nickel - analysis ; nickel(II) ; sister chromatid exchange ; Sister Chromatid Exchange - drug effects ; Solubility ; tissue culture ; Toxicology ; Welding ; welding fumes</subject><ispartof>Journal of applied toxicology, 1986-10, Vol.6 (5), p.357-362</ispartof><rights>Copyright © 1986 John Wiley & Sons, Ltd.</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4070-5fed1eb49044a771ea11b95e62dabea878ea0f86f1417d8390b631a270a3b7d43</citedby><cites>FETCH-LOGICAL-c4070-5fed1eb49044a771ea11b95e62dabea878ea0f86f1417d8390b631a270a3b7d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.2550060510$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.2550060510$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7984717$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3772012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baker, R. S. U.</creatorcontrib><creatorcontrib>Arlauskas, A.</creatorcontrib><creatorcontrib>Tandon, R. K.</creatorcontrib><creatorcontrib>Crisp, P. T.</creatorcontrib><creatorcontrib>Ellis, J.</creatorcontrib><title>Toxic and genotoxic action of electric-arc welding fumes on cultured mammalian cells</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>Welding fumes generated by manual metal arc welding (MMAW) with an automatic welding machine were extracted with water and both the soluble and insoluble fractions were investigated for mitotic delay and for sister chromatid exchange (SCE) induction in cultured Chinese hamster Iung (Don) cells. Five flux‐coated electrodes of varying composition were chosen as representative of those available. In general, watersoluble and water‐insoluble fractions induced SCE in proportion to their chromium (VI) content, and any contribution from chromium(III), fluorides, nickel, manganese or other fume constituents was minor. However, mitotic delay could not be explained in terms of the chromium(VI) concentration alone. This indicated that other components of both the soluble and insoluble fractions of the fumes were capable of inducing mitotic delay. The activity of insoluble fume fractions, either in mitotic delay‐ or in SCE‐induction, was markedly less than than that of soluble fractions. This was presumably because of the lower, though still significant, bioavailability of ‘insoluble’ components of the fume particles.</description><subject>Air Pollutants, Occupational - analysis</subject><subject>Air Pollutants, Occupational - toxicity</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cells, Cultured</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chinese hamster lung cells</subject><subject>Chromium - analysis</subject><subject>chromium(III)</subject><subject>chromium(VI)</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Fluorides - analysis</subject><subject>in vitro</subject><subject>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</subject><subject>Lung - drug effects</subject><subject>Medical sciences</subject><subject>metals</subject><subject>Mitosis - drug effects</subject><subject>mitotic delay</subject><subject>Nickel - analysis</subject><subject>nickel(II)</subject><subject>sister chromatid exchange</subject><subject>Sister Chromatid Exchange - drug effects</subject><subject>Solubility</subject><subject>tissue culture</subject><subject>Toxicology</subject><subject>Welding</subject><subject>welding fumes</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFP4zAQhS0Egm7hyg0pB64pYzuJkyNU0IWyi1h1tdysiTNBBidBdirg35NVqiJOnEYz73szo8fYMYcZBxBnT9jPRJoCZJBy2GETDkURc5HJXTYBkUGcSPVwwH6E8AQwaCLfZ_tSKQFcTNhq1b1ZE2FbRY_Udv3Ymd52bdTVETkyvbcmRm-iV3KVbR-jet1QiAbArF2_9lRFDTYNOovDiJwLh2yvRhfoaFOn7O_V5Wr-M769W1zPz29jk4CCOK2p4lQmBSQJKsUJOS-LlDJRYUmYq5wQ6jyrecJVlcsCykxyFApQlqpK5JTNxr3GdyF4qvWLtw36d81B_09HD-noz3QGw8loeFmXDVVbfBPHoJ9udAwGXe2xNTZsMVXkieJqwIoRe7WO3r85qm_OV19eiEevDT29bb3on3WmpEr1v98LPf-1XPy5uH_QS_kBxQKNNQ</recordid><startdate>198610</startdate><enddate>198610</enddate><creator>Baker, R. S. U.</creator><creator>Arlauskas, A.</creator><creator>Tandon, R. K.</creator><creator>Crisp, P. T.</creator><creator>Ellis, J.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198610</creationdate><title>Toxic and genotoxic action of electric-arc welding fumes on cultured mammalian cells</title><author>Baker, R. S. U. ; Arlauskas, A. ; Tandon, R. K. ; Crisp, P. T. ; Ellis, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4070-5fed1eb49044a771ea11b95e62dabea878ea0f86f1417d8390b631a270a3b7d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Air Pollutants, Occupational - analysis</topic><topic>Air Pollutants, Occupational - toxicity</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cells, Cultured</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chinese hamster lung cells</topic><topic>Chromium - analysis</topic><topic>chromium(III)</topic><topic>chromium(VI)</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Fluorides - analysis</topic><topic>in vitro</topic><topic>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</topic><topic>Lung - drug effects</topic><topic>Medical sciences</topic><topic>metals</topic><topic>Mitosis - drug effects</topic><topic>mitotic delay</topic><topic>Nickel - analysis</topic><topic>nickel(II)</topic><topic>sister chromatid exchange</topic><topic>Sister Chromatid Exchange - drug effects</topic><topic>Solubility</topic><topic>tissue culture</topic><topic>Toxicology</topic><topic>Welding</topic><topic>welding fumes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baker, R. S. U.</creatorcontrib><creatorcontrib>Arlauskas, A.</creatorcontrib><creatorcontrib>Tandon, R. K.</creatorcontrib><creatorcontrib>Crisp, P. T.</creatorcontrib><creatorcontrib>Ellis, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baker, R. S. U.</au><au>Arlauskas, A.</au><au>Tandon, R. K.</au><au>Crisp, P. T.</au><au>Ellis, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxic and genotoxic action of electric-arc welding fumes on cultured mammalian cells</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1986-10</date><risdate>1986</risdate><volume>6</volume><issue>5</issue><spage>357</spage><epage>362</epage><pages>357-362</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>Welding fumes generated by manual metal arc welding (MMAW) with an automatic welding machine were extracted with water and both the soluble and insoluble fractions were investigated for mitotic delay and for sister chromatid exchange (SCE) induction in cultured Chinese hamster Iung (Don) cells. Five flux‐coated electrodes of varying composition were chosen as representative of those available. In general, watersoluble and water‐insoluble fractions induced SCE in proportion to their chromium (VI) content, and any contribution from chromium(III), fluorides, nickel, manganese or other fume constituents was minor. However, mitotic delay could not be explained in terms of the chromium(VI) concentration alone. This indicated that other components of both the soluble and insoluble fractions of the fumes were capable of inducing mitotic delay. The activity of insoluble fume fractions, either in mitotic delay‐ or in SCE‐induction, was markedly less than than that of soluble fractions. This was presumably because of the lower, though still significant, bioavailability of ‘insoluble’ components of the fume particles.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>3772012</pmid><doi>10.1002/jat.2550060510</doi><tpages>6</tpages></addata></record> |
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| subjects | Air Pollutants, Occupational - analysis Air Pollutants, Occupational - toxicity Animals Biological and medical sciences Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Chinese hamster lung cells Chromium - analysis chromium(III) chromium(VI) Cricetinae Cricetulus Fluorides - analysis in vitro Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Lung - drug effects Medical sciences metals Mitosis - drug effects mitotic delay Nickel - analysis nickel(II) sister chromatid exchange Sister Chromatid Exchange - drug effects Solubility tissue culture Toxicology Welding welding fumes |
| title | Toxic and genotoxic action of electric-arc welding fumes on cultured mammalian cells |
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