Developmental toxicity following oral administration of a high-boiling coal liquid to pregnant rats
Heavy distillate (HD), the highest‐boiling coal liquid from the solvent‐refined coal‐II process (SRC‐II), was administered by intragastric (IG) intubation to pregnant rats. Five dose levels of HD (0.09, 0.14, 0.18, 0.36 and 0.74 g kg−1), were given daily from 12 to 16 days of gestation and the rats...
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| Veröffentlicht in: | Journal of applied toxicology 1984-02, Vol.4 (1), p.57-62 |
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| creator | Hackett, P. L. Rommereim, D. N. Sikov, M. R. |
| description | Heavy distillate (HD), the highest‐boiling coal liquid from the solvent‐refined coal‐II process (SRC‐II), was administered by intragastric (IG) intubation to pregnant rats. Five dose levels of HD (0.09, 0.14, 0.18, 0.36 and 0.74 g kg−1), were given daily from 12 to 16 days of gestation and the rats were killed at 20 days of gestation. Maternal body weights and weights of the liver, kidneys, spleen, adrenals, thymus, ovaries and the gravid uterus were obtained. Gravid uteri were evaluated for prenatal mortality. Live fetuses were examined for malformations and weighed; fetal lungs were excised and weighed. Maternal (extragestational) weight gains and thymic weights diminished in all groups that received the SRC material. Adrenal weights were increased in all treated animals, except for those in the lowest‐dose group (0.9 g kg−1). There was significant maternal mortality at 0.74 g kg−1 and increased intrauterine mortality at doses of 0.37 and 0.74 g kg−1. Placental weight was depressed, and the incidence of fetal anomalies was increased at 0.14 g kg−1 and all higher dose levels. |
| doi_str_mv | 10.1002/jat.2550040111 |
| format | Article |
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L. ; Rommereim, D. N. ; Sikov, M. R.</creator><creatorcontrib>Hackett, P. L. ; Rommereim, D. N. ; Sikov, M. R.</creatorcontrib><description>Heavy distillate (HD), the highest‐boiling coal liquid from the solvent‐refined coal‐II process (SRC‐II), was administered by intragastric (IG) intubation to pregnant rats. Five dose levels of HD (0.09, 0.14, 0.18, 0.36 and 0.74 g kg−1), were given daily from 12 to 16 days of gestation and the rats were killed at 20 days of gestation. Maternal body weights and weights of the liver, kidneys, spleen, adrenals, thymus, ovaries and the gravid uterus were obtained. Gravid uteri were evaluated for prenatal mortality. Live fetuses were examined for malformations and weighed; fetal lungs were excised and weighed. Maternal (extragestational) weight gains and thymic weights diminished in all groups that received the SRC material. Adrenal weights were increased in all treated animals, except for those in the lowest‐dose group (0.9 g kg−1). There was significant maternal mortality at 0.74 g kg−1 and increased intrauterine mortality at doses of 0.37 and 0.74 g kg−1. Placental weight was depressed, and the incidence of fetal anomalies was increased at 0.14 g kg−1 and all higher dose levels.</description><identifier>ISSN: 0260-437X</identifier><identifier>EISSN: 1099-1263</identifier><identifier>DOI: 10.1002/jat.2550040111</identifier><identifier>PMID: 6715782</identifier><identifier>CODEN: JJATDK</identifier><language>eng</language><publisher>Chichester: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; Body Weight - drug effects ; Coal - toxicity ; coal liquid ; Embryo, Mammalian - drug effects ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; gastric intubation ; Gestational Age ; Lung - drug effects ; Organ Size - drug effects ; Placenta - drug effects ; Pregnancy ; Pregnancy, Animal - drug effects ; rat ; Rats ; Rats, Inbred Strains ; teratogenicity ; Teratogens ; Teratology. Teratogens</subject><ispartof>Journal of applied toxicology, 1984-02, Vol.4 (1), p.57-62</ispartof><rights>Copyright © 1984 John Wiley & Sons, Ltd.</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4071-8b6f2506155cac6c22d5640e4300383dbbea2a9787332cb3aa39f02ce7f5443f3</citedby><cites>FETCH-LOGICAL-c4071-8b6f2506155cac6c22d5640e4300383dbbea2a9787332cb3aa39f02ce7f5443f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjat.2550040111$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjat.2550040111$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9551555$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6715782$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hackett, P. L.</creatorcontrib><creatorcontrib>Rommereim, D. N.</creatorcontrib><creatorcontrib>Sikov, M. R.</creatorcontrib><title>Developmental toxicity following oral administration of a high-boiling coal liquid to pregnant rats</title><title>Journal of applied toxicology</title><addtitle>J. Appl. Toxicol</addtitle><description>Heavy distillate (HD), the highest‐boiling coal liquid from the solvent‐refined coal‐II process (SRC‐II), was administered by intragastric (IG) intubation to pregnant rats. Five dose levels of HD (0.09, 0.14, 0.18, 0.36 and 0.74 g kg−1), were given daily from 12 to 16 days of gestation and the rats were killed at 20 days of gestation. Maternal body weights and weights of the liver, kidneys, spleen, adrenals, thymus, ovaries and the gravid uterus were obtained. Gravid uteri were evaluated for prenatal mortality. Live fetuses were examined for malformations and weighed; fetal lungs were excised and weighed. Maternal (extragestational) weight gains and thymic weights diminished in all groups that received the SRC material. Adrenal weights were increased in all treated animals, except for those in the lowest‐dose group (0.9 g kg−1). There was significant maternal mortality at 0.74 g kg−1 and increased intrauterine mortality at doses of 0.37 and 0.74 g kg−1. Placental weight was depressed, and the incidence of fetal anomalies was increased at 0.14 g kg−1 and all higher dose levels.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Coal - toxicity</subject><subject>coal liquid</subject><subject>Embryo, Mammalian - drug effects</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gastric intubation</subject><subject>Gestational Age</subject><subject>Lung - drug effects</subject><subject>Organ Size - drug effects</subject><subject>Placenta - drug effects</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - drug effects</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>teratogenicity</subject><subject>Teratogens</subject><subject>Teratology. Teratogens</subject><issn>0260-437X</issn><issn>1099-1263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1PGzEQxS1URAPl2lulPfS66dhe78cRhSa0ikBCqeBmzXrtYOqsU3spyX-Po0SpOPU00rzfm3l6hHymMKYA7NszDmMmBEABlNITMqLQNDllJf9ARsBKyAtePX4k5zE-AySN1WfkrKyoqGo2Iupa_9XOr1e6H9Blg99YZYdtZrxz_tX2y8yHtMduZXsbh4CD9X3mTYbZk10-5a23bkcpnyhn_7zYLh3J1kEve-yHLBniJ3Jq0EV9eZgX5Nf0-2Jyk8_vZj8mV_NcFVDRvG5LwwSUVAiFqlSMdaIsQBccgNe8a1uNDJuqrjhnquWIvDHAlK6MKApu-AUZ7--q4GMM2sh1sCsMW0lB7sqSqSz5r6xk-LI3rF_ale6O-KGdpH896BgVOhOwVzYesUaIlFUkrNljr9bp7X-eyp9Xi3cR8r03las3Ry-G3ykFr4R8uJ3J2eR6Om1mU3nP3wCVW5Ll</recordid><startdate>198402</startdate><enddate>198402</enddate><creator>Hackett, P. L.</creator><creator>Rommereim, D. N.</creator><creator>Sikov, M. R.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198402</creationdate><title>Developmental toxicity following oral administration of a high-boiling coal liquid to pregnant rats</title><author>Hackett, P. L. ; Rommereim, D. N. ; Sikov, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4071-8b6f2506155cac6c22d5640e4300383dbbea2a9787332cb3aa39f02ce7f5443f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Coal - toxicity</topic><topic>coal liquid</topic><topic>Embryo, Mammalian - drug effects</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gastric intubation</topic><topic>Gestational Age</topic><topic>Lung - drug effects</topic><topic>Organ Size - drug effects</topic><topic>Placenta - drug effects</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - drug effects</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>teratogenicity</topic><topic>Teratogens</topic><topic>Teratology. Teratogens</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hackett, P. L.</creatorcontrib><creatorcontrib>Rommereim, D. N.</creatorcontrib><creatorcontrib>Sikov, M. R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of applied toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hackett, P. L.</au><au>Rommereim, D. N.</au><au>Sikov, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Developmental toxicity following oral administration of a high-boiling coal liquid to pregnant rats</atitle><jtitle>Journal of applied toxicology</jtitle><addtitle>J. Appl. Toxicol</addtitle><date>1984-02</date><risdate>1984</risdate><volume>4</volume><issue>1</issue><spage>57</spage><epage>62</epage><pages>57-62</pages><issn>0260-437X</issn><eissn>1099-1263</eissn><coden>JJATDK</coden><abstract>Heavy distillate (HD), the highest‐boiling coal liquid from the solvent‐refined coal‐II process (SRC‐II), was administered by intragastric (IG) intubation to pregnant rats. Five dose levels of HD (0.09, 0.14, 0.18, 0.36 and 0.74 g kg−1), were given daily from 12 to 16 days of gestation and the rats were killed at 20 days of gestation. Maternal body weights and weights of the liver, kidneys, spleen, adrenals, thymus, ovaries and the gravid uterus were obtained. Gravid uteri were evaluated for prenatal mortality. Live fetuses were examined for malformations and weighed; fetal lungs were excised and weighed. Maternal (extragestational) weight gains and thymic weights diminished in all groups that received the SRC material. Adrenal weights were increased in all treated animals, except for those in the lowest‐dose group (0.9 g kg−1). There was significant maternal mortality at 0.74 g kg−1 and increased intrauterine mortality at doses of 0.37 and 0.74 g kg−1. Placental weight was depressed, and the incidence of fetal anomalies was increased at 0.14 g kg−1 and all higher dose levels.</abstract><cop>Chichester</cop><pub>John Wiley & Sons, Ltd</pub><pmid>6715782</pmid><doi>10.1002/jat.2550040111</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Body Weight - drug effects Coal - toxicity coal liquid Embryo, Mammalian - drug effects Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology gastric intubation Gestational Age Lung - drug effects Organ Size - drug effects Placenta - drug effects Pregnancy Pregnancy, Animal - drug effects rat Rats Rats, Inbred Strains teratogenicity Teratogens Teratology. Teratogens |
| title | Developmental toxicity following oral administration of a high-boiling coal liquid to pregnant rats |
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