PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer
Estrogen exhibits mitogenic activity in early ovarian carcinogenesis and plays an important role in ovarian tumorigenesis. Due to the increased expression of ERα and decreased expression of the ERβ, the ratio of ERα and ERβ is markedly increased in ovarian cancer. We have recently reported that PES1...
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| Veröffentlicht in: | IUBMB life 2013-12, Vol.65 (12), p.1017-1025 |
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| creator | Li, Jieping Zhuang, Qinren Lan, Xiaopeng Zeng, Guobin Jiang, Xuping Huang, Zongming |
| description | Estrogen exhibits mitogenic activity in early ovarian carcinogenesis and plays an important role in ovarian tumorigenesis. Due to the increased expression of ERα and decreased expression of the ERβ, the ratio of ERα and ERβ is markedly increased in ovarian cancer. We have recently reported that PES1 regulates the balance of ERα and ERβ at the post‐transcriptional level in breast cancer. Here, we report that PES1 inversely regulates the expression of ERα and ERβ in addition to their transcriptional activities in epithelial ovarian cancer. We found that the ablation of PES1 resulted in the significant downregulation of ERα and estrogen‐responsive genes such as cylin D1, HIF‐1α and VEGF and the up‐regulation of ERβ and p21WAF1. Cell proliferation in both tested ovarian cell lines was markedly inhibited and cells were arrested in G2 after PES1 was ablated. Further analysis of clinical samples showed that expression of PES1 correlated positively with ERα expression and negatively with ERβ expression. Our results demonstrate that PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERα and ERβ expression. PES1 may be a new target for ovarian cancer therapy. © 2013 IUBMB Life, 65(12):1017–1025, 2013. |
| doi_str_mv | 10.1002/iub.1228 |
| format | Article |
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Due to the increased expression of ERα and decreased expression of the ERβ, the ratio of ERα and ERβ is markedly increased in ovarian cancer. We have recently reported that PES1 regulates the balance of ERα and ERβ at the post‐transcriptional level in breast cancer. Here, we report that PES1 inversely regulates the expression of ERα and ERβ in addition to their transcriptional activities in epithelial ovarian cancer. We found that the ablation of PES1 resulted in the significant downregulation of ERα and estrogen‐responsive genes such as cylin D1, HIF‐1α and VEGF and the up‐regulation of ERβ and p21WAF1. Cell proliferation in both tested ovarian cell lines was markedly inhibited and cells were arrested in G2 after PES1 was ablated. Further analysis of clinical samples showed that expression of PES1 correlated positively with ERα expression and negatively with ERβ expression. Our results demonstrate that PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERα and ERβ expression. PES1 may be a new target for ovarian cancer therapy. © 2013 IUBMB Life, 65(12):1017–1025, 2013.</description><identifier>ISSN: 1521-6543</identifier><identifier>EISSN: 1521-6551</identifier><identifier>DOI: 10.1002/iub.1228</identifier><identifier>PMID: 24376209</identifier><language>eng</language><publisher>England</publisher><subject>Case-Control Studies ; Cell Proliferation ; estrogen receptor alpha ; Estrogen Receptor alpha - genetics ; Estrogen Receptor alpha - metabolism ; estrogen receptor beta ; Estrogen Receptor beta - genetics ; Estrogen Receptor beta - metabolism ; Female ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; MCF-7 Cells ; ovarian cancer ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - metabolism ; Ovary - metabolism ; Ovary - pathology ; pescadillo/PES1 ; Proteins - physiology ; Transcription, Genetic ; transcriptional activity</subject><ispartof>IUBMB life, 2013-12, Vol.65 (12), p.1017-1025</ispartof><rights>2013 International Union of Biochemistry and Molecular Biology</rights><rights>2013 International Union of Biochemistry and Molecular Biology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3218-dc2cfc16e7f67985f308fd6ba757c0480db7fa662d961a6717bdb927d2444be73</citedby><cites>FETCH-LOGICAL-c3218-dc2cfc16e7f67985f308fd6ba757c0480db7fa662d961a6717bdb927d2444be73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fiub.1228$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fiub.1228$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24376209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Jieping</creatorcontrib><creatorcontrib>Zhuang, Qinren</creatorcontrib><creatorcontrib>Lan, Xiaopeng</creatorcontrib><creatorcontrib>Zeng, Guobin</creatorcontrib><creatorcontrib>Jiang, Xuping</creatorcontrib><creatorcontrib>Huang, Zongming</creatorcontrib><title>PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer</title><title>IUBMB life</title><addtitle>IUBMB Life</addtitle><description>Estrogen exhibits mitogenic activity in early ovarian carcinogenesis and plays an important role in ovarian tumorigenesis. Due to the increased expression of ERα and decreased expression of the ERβ, the ratio of ERα and ERβ is markedly increased in ovarian cancer. We have recently reported that PES1 regulates the balance of ERα and ERβ at the post‐transcriptional level in breast cancer. Here, we report that PES1 inversely regulates the expression of ERα and ERβ in addition to their transcriptional activities in epithelial ovarian cancer. We found that the ablation of PES1 resulted in the significant downregulation of ERα and estrogen‐responsive genes such as cylin D1, HIF‐1α and VEGF and the up‐regulation of ERβ and p21WAF1. Cell proliferation in both tested ovarian cell lines was markedly inhibited and cells were arrested in G2 after PES1 was ablated. Further analysis of clinical samples showed that expression of PES1 correlated positively with ERα expression and negatively with ERβ expression. Our results demonstrate that PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERα and ERβ expression. PES1 may be a new target for ovarian cancer therapy. © 2013 IUBMB Life, 65(12):1017–1025, 2013.</description><subject>Case-Control Studies</subject><subject>Cell Proliferation</subject><subject>estrogen receptor alpha</subject><subject>Estrogen Receptor alpha - genetics</subject><subject>Estrogen Receptor alpha - metabolism</subject><subject>estrogen receptor beta</subject><subject>Estrogen Receptor beta - genetics</subject><subject>Estrogen Receptor beta - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>MCF-7 Cells</subject><subject>ovarian cancer</subject><subject>Ovarian Neoplasms - genetics</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovary - metabolism</subject><subject>Ovary - pathology</subject><subject>pescadillo/PES1</subject><subject>Proteins - physiology</subject><subject>Transcription, Genetic</subject><subject>transcriptional activity</subject><issn>1521-6543</issn><issn>1521-6551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAURS0EoqUgsQLkIZMU20nsZAhVgEqVioCOI3-ewShNKrsFsixYCGsiodAZb_Kuro7u4CB0SsmYEsIu3EaNKWPZHhrSlNGIpynd3-UkHqCjEF5Id4Lkh2jAklhwRvIhmt8VDxQbZy14qNdOVlWLPTxtKrmGgNfPgOF95SEE19S4sbi4__rAsjZ9-MSu616ld7LGWtYa_DE6sLIKcPL7R2hxXTxObqPZ_GY6uZxFOmY0i4xm2mrKQVgu8iy1Mcms4UqKVGiSZMQoYSXnzOScSi6oUEblTBiWJIkCEY_Q-XZX-yYED7ZcebeUvi0pKXsnZeek7J106NkWXW3UEswO_JPQAdEWeHMVtP8OldPF1c_gNxsba5M</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Li, Jieping</creator><creator>Zhuang, Qinren</creator><creator>Lan, Xiaopeng</creator><creator>Zeng, Guobin</creator><creator>Jiang, Xuping</creator><creator>Huang, Zongming</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201312</creationdate><title>PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer</title><author>Li, Jieping ; Zhuang, Qinren ; Lan, Xiaopeng ; Zeng, Guobin ; Jiang, Xuping ; Huang, Zongming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3218-dc2cfc16e7f67985f308fd6ba757c0480db7fa662d961a6717bdb927d2444be73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Case-Control Studies</topic><topic>Cell Proliferation</topic><topic>estrogen receptor alpha</topic><topic>Estrogen Receptor alpha - genetics</topic><topic>Estrogen Receptor alpha - metabolism</topic><topic>estrogen receptor beta</topic><topic>Estrogen Receptor beta - genetics</topic><topic>Estrogen Receptor beta - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>HEK293 Cells</topic><topic>Humans</topic><topic>MCF-7 Cells</topic><topic>ovarian cancer</topic><topic>Ovarian Neoplasms - genetics</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovary - metabolism</topic><topic>Ovary - pathology</topic><topic>pescadillo/PES1</topic><topic>Proteins - physiology</topic><topic>Transcription, Genetic</topic><topic>transcriptional activity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jieping</creatorcontrib><creatorcontrib>Zhuang, Qinren</creatorcontrib><creatorcontrib>Lan, Xiaopeng</creatorcontrib><creatorcontrib>Zeng, Guobin</creatorcontrib><creatorcontrib>Jiang, Xuping</creatorcontrib><creatorcontrib>Huang, Zongming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>IUBMB life</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jieping</au><au>Zhuang, Qinren</au><au>Lan, Xiaopeng</au><au>Zeng, Guobin</au><au>Jiang, Xuping</au><au>Huang, Zongming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer</atitle><jtitle>IUBMB life</jtitle><addtitle>IUBMB Life</addtitle><date>2013-12</date><risdate>2013</risdate><volume>65</volume><issue>12</issue><spage>1017</spage><epage>1025</epage><pages>1017-1025</pages><issn>1521-6543</issn><eissn>1521-6551</eissn><abstract>Estrogen exhibits mitogenic activity in early ovarian carcinogenesis and plays an important role in ovarian tumorigenesis. Due to the increased expression of ERα and decreased expression of the ERβ, the ratio of ERα and ERβ is markedly increased in ovarian cancer. We have recently reported that PES1 regulates the balance of ERα and ERβ at the post‐transcriptional level in breast cancer. Here, we report that PES1 inversely regulates the expression of ERα and ERβ in addition to their transcriptional activities in epithelial ovarian cancer. We found that the ablation of PES1 resulted in the significant downregulation of ERα and estrogen‐responsive genes such as cylin D1, HIF‐1α and VEGF and the up‐regulation of ERβ and p21WAF1. Cell proliferation in both tested ovarian cell lines was markedly inhibited and cells were arrested in G2 after PES1 was ablated. Further analysis of clinical samples showed that expression of PES1 correlated positively with ERα expression and negatively with ERβ expression. Our results demonstrate that PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERα and ERβ expression. PES1 may be a new target for ovarian cancer therapy. © 2013 IUBMB Life, 65(12):1017–1025, 2013.</abstract><cop>England</cop><pmid>24376209</pmid><doi>10.1002/iub.1228</doi><tpages>9</tpages></addata></record> |
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| subjects | Case-Control Studies Cell Proliferation estrogen receptor alpha Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism estrogen receptor beta Estrogen Receptor beta - genetics Estrogen Receptor beta - metabolism Female Gene Expression Regulation, Neoplastic HEK293 Cells Humans MCF-7 Cells ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovary - metabolism Ovary - pathology pescadillo/PES1 Proteins - physiology Transcription, Genetic transcriptional activity |
| title | PES1 differentially regulates the expression of ERα and ERβ in ovarian cancer |
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