Potential causal links of long-term exposure to PM 2.5 and its chemical components with the risk of nasopharyngeal carcinoma recurrence: A 10-year cohort study in South China
There is a lack of evidence from cohort studies on the causal association of long-term exposure to ambient fine particulate matter (PM ) and its chemical components with the risk of nasopharyngeal carcinoma (NPC) recurrence. Based on a 10-year prospective cohort of 1184 newly diagnosed NPC patients,...
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creator | Sun, Xurui Lin, Xiao Yao, Jijin Tian, Tian Li, Zhiqiang Chen, Shimin Hu, Weihua Jiang, Jie Tang, Hui Cai, Huanle Guo, Tong Chen, Xudan Chen, Zhibing Zhang, Man Sun, Yongqing Lin, Shao Qu, Yanji Deng, Xinlei Lin, Ziqiang Xia, Liangping Jin, Yanan Zhang, Wangjian |
description | There is a lack of evidence from cohort studies on the causal association of long-term exposure to ambient fine particulate matter (PM
) and its chemical components with the risk of nasopharyngeal carcinoma (NPC) recurrence. Based on a 10-year prospective cohort of 1184 newly diagnosed NPC patients, we comprehensively evaluated the potential causal links of ambient PM
and its chemical components including black carbon (BC), organic matter (OM), sulfate (SO
), nitrate (NO
), and ammonium (NH
) with the recurrence risk of NPC using a marginal structural Cox model adjusted with inverse probability weighting. We observed 291 NPC patients experiencing recurrence during the 10-year follow-up and estimated a 33% increased risk of NPC recurrence (hazard ratio [HR]: 1.33, 95% confidence interval [CI]: 1.02-1.74) following each interquartile range (IQR) increase in PM
exposure. Each IQR increment in BC, NH
, OM, NO
, and SO
was associated with HRs of 1.36 (95%CI: 1.13-1.65), 1.35 (95%CI: 1.07-1.70), 1.33 (95%CI: 1.11-1.59), 1.32 (95%CI: 1.06-1.64), 1.31 (95%CI: 1.08-1.57). The elderly, patients with no family history of cancer, no smoking history, no drinking history, and those with severe conditions may exhibit a greater likelihood of NPC recurrence following exposure to PM
and its chemical components. Additionally, the effect estimates of the five components are greater among patients who were exposed to high concentration than in the full cohort of patients. Our study provides solid evidence for a potential relationship between long-term exposure to PM
and its components and the risk of NPC recurrence. |
doi_str_mv | 10.1002/ijc.35047 |
format | Article |
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) and its chemical components with the risk of nasopharyngeal carcinoma (NPC) recurrence. Based on a 10-year prospective cohort of 1184 newly diagnosed NPC patients, we comprehensively evaluated the potential causal links of ambient PM
and its chemical components including black carbon (BC), organic matter (OM), sulfate (SO
), nitrate (NO
), and ammonium (NH
) with the recurrence risk of NPC using a marginal structural Cox model adjusted with inverse probability weighting. We observed 291 NPC patients experiencing recurrence during the 10-year follow-up and estimated a 33% increased risk of NPC recurrence (hazard ratio [HR]: 1.33, 95% confidence interval [CI]: 1.02-1.74) following each interquartile range (IQR) increase in PM
exposure. Each IQR increment in BC, NH
, OM, NO
, and SO
was associated with HRs of 1.36 (95%CI: 1.13-1.65), 1.35 (95%CI: 1.07-1.70), 1.33 (95%CI: 1.11-1.59), 1.32 (95%CI: 1.06-1.64), 1.31 (95%CI: 1.08-1.57). The elderly, patients with no family history of cancer, no smoking history, no drinking history, and those with severe conditions may exhibit a greater likelihood of NPC recurrence following exposure to PM
and its chemical components. Additionally, the effect estimates of the five components are greater among patients who were exposed to high concentration than in the full cohort of patients. Our study provides solid evidence for a potential relationship between long-term exposure to PM
and its components and the risk of NPC recurrence.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.35047</identifier><identifier>PMID: 38863244</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Air Pollutants - adverse effects ; Air Pollutants - analysis ; Air Pollution - adverse effects ; China - epidemiology ; Cohort Studies ; Environmental Exposure - adverse effects ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Nasopharyngeal Carcinoma - epidemiology ; Nasopharyngeal Carcinoma - etiology ; Nasopharyngeal Neoplasms - epidemiology ; Nasopharyngeal Neoplasms - etiology ; Neoplasm Recurrence, Local - epidemiology ; Particulate Matter - adverse effects ; Prospective Studies ; Risk Factors</subject><ispartof>International journal of cancer, 2024-11, Vol.155 (9), p.1558-1566</ispartof><rights>2024 UICC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c574-d4757637059338c0e49d977d8965f205e7d753361c35f807fb59a667067f07393</cites><orcidid>0000-0003-4934-4165 ; 0000-0001-9655-6385</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38863244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sun, Xurui</creatorcontrib><creatorcontrib>Lin, Xiao</creatorcontrib><creatorcontrib>Yao, Jijin</creatorcontrib><creatorcontrib>Tian, Tian</creatorcontrib><creatorcontrib>Li, Zhiqiang</creatorcontrib><creatorcontrib>Chen, Shimin</creatorcontrib><creatorcontrib>Hu, Weihua</creatorcontrib><creatorcontrib>Jiang, Jie</creatorcontrib><creatorcontrib>Tang, Hui</creatorcontrib><creatorcontrib>Cai, Huanle</creatorcontrib><creatorcontrib>Guo, Tong</creatorcontrib><creatorcontrib>Chen, Xudan</creatorcontrib><creatorcontrib>Chen, Zhibing</creatorcontrib><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Sun, Yongqing</creatorcontrib><creatorcontrib>Lin, Shao</creatorcontrib><creatorcontrib>Qu, Yanji</creatorcontrib><creatorcontrib>Deng, Xinlei</creatorcontrib><creatorcontrib>Lin, Ziqiang</creatorcontrib><creatorcontrib>Xia, Liangping</creatorcontrib><creatorcontrib>Jin, Yanan</creatorcontrib><creatorcontrib>Zhang, Wangjian</creatorcontrib><title>Potential causal links of long-term exposure to PM 2.5 and its chemical components with the risk of nasopharyngeal carcinoma recurrence: A 10-year cohort study in South China</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>There is a lack of evidence from cohort studies on the causal association of long-term exposure to ambient fine particulate matter (PM
) and its chemical components with the risk of nasopharyngeal carcinoma (NPC) recurrence. Based on a 10-year prospective cohort of 1184 newly diagnosed NPC patients, we comprehensively evaluated the potential causal links of ambient PM
and its chemical components including black carbon (BC), organic matter (OM), sulfate (SO
), nitrate (NO
), and ammonium (NH
) with the recurrence risk of NPC using a marginal structural Cox model adjusted with inverse probability weighting. We observed 291 NPC patients experiencing recurrence during the 10-year follow-up and estimated a 33% increased risk of NPC recurrence (hazard ratio [HR]: 1.33, 95% confidence interval [CI]: 1.02-1.74) following each interquartile range (IQR) increase in PM
exposure. Each IQR increment in BC, NH
, OM, NO
, and SO
was associated with HRs of 1.36 (95%CI: 1.13-1.65), 1.35 (95%CI: 1.07-1.70), 1.33 (95%CI: 1.11-1.59), 1.32 (95%CI: 1.06-1.64), 1.31 (95%CI: 1.08-1.57). The elderly, patients with no family history of cancer, no smoking history, no drinking history, and those with severe conditions may exhibit a greater likelihood of NPC recurrence following exposure to PM
and its chemical components. Additionally, the effect estimates of the five components are greater among patients who were exposed to high concentration than in the full cohort of patients. Our study provides solid evidence for a potential relationship between long-term exposure to PM
and its components and the risk of NPC recurrence.</description><subject>Adult</subject><subject>Aged</subject><subject>Air Pollutants - adverse effects</subject><subject>Air Pollutants - analysis</subject><subject>Air Pollution - adverse effects</subject><subject>China - epidemiology</subject><subject>Cohort Studies</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Carcinoma - epidemiology</subject><subject>Nasopharyngeal Carcinoma - etiology</subject><subject>Nasopharyngeal Neoplasms - epidemiology</subject><subject>Nasopharyngeal Neoplasms - etiology</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Particulate Matter - adverse effects</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kLtOxDAQRS0EguVR8ANoWoos4ziOEzq04iWBQII-Mo5DDBs7sh3B_hTfiHd5VLeYM2c0l5BjinOKmJ-ZNzVnHAuxRWYUa5FhTvk2maUZZoKyco_sh_CGSGmidskeq6qS5UUxI1-PLmobjVyCklNIsTT2PYDrYOnsaxa1H0B_ji5MXkN08HgP-ZyDtC2YGED1ejBqve2G0dmkCvBhYg-x1-BNeF-brAxu7KVf2Ve9OeSVsW6Q4LWavNdW6XO4AIrZSkufVL3zEUKc2hUYC09uSsJFb6w8JDudXAZ99JsH5Pnq8nlxk909XN8uLu4yxUWRtYXgomQCec1YpVAXdVsL0VZ1ybscuRat4IyVVDHeVSi6F17LshRYig4Fq9kBOf3RKu9C8LprRm-G9EBDsVlX3qTKm03liT35YcfpZdDtP_nXMfsG4xF85Q</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Sun, Xurui</creator><creator>Lin, Xiao</creator><creator>Yao, Jijin</creator><creator>Tian, Tian</creator><creator>Li, Zhiqiang</creator><creator>Chen, Shimin</creator><creator>Hu, Weihua</creator><creator>Jiang, Jie</creator><creator>Tang, Hui</creator><creator>Cai, Huanle</creator><creator>Guo, Tong</creator><creator>Chen, Xudan</creator><creator>Chen, Zhibing</creator><creator>Zhang, Man</creator><creator>Sun, Yongqing</creator><creator>Lin, Shao</creator><creator>Qu, Yanji</creator><creator>Deng, Xinlei</creator><creator>Lin, Ziqiang</creator><creator>Xia, Liangping</creator><creator>Jin, Yanan</creator><creator>Zhang, Wangjian</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-4934-4165</orcidid><orcidid>https://orcid.org/0000-0001-9655-6385</orcidid></search><sort><creationdate>20241101</creationdate><title>Potential causal links of long-term exposure to PM 2.5 and its chemical components with the risk of nasopharyngeal carcinoma recurrence: A 10-year cohort study in South China</title><author>Sun, Xurui ; Lin, Xiao ; Yao, Jijin ; Tian, Tian ; Li, Zhiqiang ; Chen, Shimin ; Hu, Weihua ; Jiang, Jie ; Tang, Hui ; Cai, Huanle ; Guo, Tong ; Chen, Xudan ; Chen, Zhibing ; Zhang, Man ; Sun, Yongqing ; Lin, Shao ; Qu, Yanji ; Deng, Xinlei ; Lin, Ziqiang ; Xia, Liangping ; Jin, Yanan ; Zhang, Wangjian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c574-d4757637059338c0e49d977d8965f205e7d753361c35f807fb59a667067f07393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Air Pollutants - adverse effects</topic><topic>Air Pollutants - analysis</topic><topic>Air Pollution - adverse effects</topic><topic>China - epidemiology</topic><topic>Cohort Studies</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Carcinoma - epidemiology</topic><topic>Nasopharyngeal Carcinoma - etiology</topic><topic>Nasopharyngeal Neoplasms - epidemiology</topic><topic>Nasopharyngeal Neoplasms - etiology</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Particulate Matter - adverse effects</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Xurui</creatorcontrib><creatorcontrib>Lin, Xiao</creatorcontrib><creatorcontrib>Yao, Jijin</creatorcontrib><creatorcontrib>Tian, Tian</creatorcontrib><creatorcontrib>Li, Zhiqiang</creatorcontrib><creatorcontrib>Chen, Shimin</creatorcontrib><creatorcontrib>Hu, Weihua</creatorcontrib><creatorcontrib>Jiang, Jie</creatorcontrib><creatorcontrib>Tang, Hui</creatorcontrib><creatorcontrib>Cai, Huanle</creatorcontrib><creatorcontrib>Guo, Tong</creatorcontrib><creatorcontrib>Chen, Xudan</creatorcontrib><creatorcontrib>Chen, Zhibing</creatorcontrib><creatorcontrib>Zhang, Man</creatorcontrib><creatorcontrib>Sun, Yongqing</creatorcontrib><creatorcontrib>Lin, Shao</creatorcontrib><creatorcontrib>Qu, Yanji</creatorcontrib><creatorcontrib>Deng, Xinlei</creatorcontrib><creatorcontrib>Lin, Ziqiang</creatorcontrib><creatorcontrib>Xia, Liangping</creatorcontrib><creatorcontrib>Jin, Yanan</creatorcontrib><creatorcontrib>Zhang, Wangjian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Xurui</au><au>Lin, Xiao</au><au>Yao, Jijin</au><au>Tian, Tian</au><au>Li, Zhiqiang</au><au>Chen, Shimin</au><au>Hu, Weihua</au><au>Jiang, Jie</au><au>Tang, Hui</au><au>Cai, Huanle</au><au>Guo, Tong</au><au>Chen, Xudan</au><au>Chen, Zhibing</au><au>Zhang, Man</au><au>Sun, Yongqing</au><au>Lin, Shao</au><au>Qu, Yanji</au><au>Deng, Xinlei</au><au>Lin, Ziqiang</au><au>Xia, Liangping</au><au>Jin, Yanan</au><au>Zhang, Wangjian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Potential causal links of long-term exposure to PM 2.5 and its chemical components with the risk of nasopharyngeal carcinoma recurrence: A 10-year cohort study in South China</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>155</volume><issue>9</issue><spage>1558</spage><epage>1566</epage><pages>1558-1566</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>There is a lack of evidence from cohort studies on the causal association of long-term exposure to ambient fine particulate matter (PM
) and its chemical components with the risk of nasopharyngeal carcinoma (NPC) recurrence. Based on a 10-year prospective cohort of 1184 newly diagnosed NPC patients, we comprehensively evaluated the potential causal links of ambient PM
and its chemical components including black carbon (BC), organic matter (OM), sulfate (SO
), nitrate (NO
), and ammonium (NH
) with the recurrence risk of NPC using a marginal structural Cox model adjusted with inverse probability weighting. We observed 291 NPC patients experiencing recurrence during the 10-year follow-up and estimated a 33% increased risk of NPC recurrence (hazard ratio [HR]: 1.33, 95% confidence interval [CI]: 1.02-1.74) following each interquartile range (IQR) increase in PM
exposure. Each IQR increment in BC, NH
, OM, NO
, and SO
was associated with HRs of 1.36 (95%CI: 1.13-1.65), 1.35 (95%CI: 1.07-1.70), 1.33 (95%CI: 1.11-1.59), 1.32 (95%CI: 1.06-1.64), 1.31 (95%CI: 1.08-1.57). The elderly, patients with no family history of cancer, no smoking history, no drinking history, and those with severe conditions may exhibit a greater likelihood of NPC recurrence following exposure to PM
and its chemical components. Additionally, the effect estimates of the five components are greater among patients who were exposed to high concentration than in the full cohort of patients. Our study provides solid evidence for a potential relationship between long-term exposure to PM
and its components and the risk of NPC recurrence.</abstract><cop>United States</cop><pmid>38863244</pmid><doi>10.1002/ijc.35047</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4934-4165</orcidid><orcidid>https://orcid.org/0000-0001-9655-6385</orcidid></addata></record> |
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subjects | Adult Aged Air Pollutants - adverse effects Air Pollutants - analysis Air Pollution - adverse effects China - epidemiology Cohort Studies Environmental Exposure - adverse effects Female Follow-Up Studies Humans Male Middle Aged Nasopharyngeal Carcinoma - epidemiology Nasopharyngeal Carcinoma - etiology Nasopharyngeal Neoplasms - epidemiology Nasopharyngeal Neoplasms - etiology Neoplasm Recurrence, Local - epidemiology Particulate Matter - adverse effects Prospective Studies Risk Factors |
title | Potential causal links of long-term exposure to PM 2.5 and its chemical components with the risk of nasopharyngeal carcinoma recurrence: A 10-year cohort study in South China |
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