Multiple mechanisms of resistance in a series of human testicular teratoma cell lines selected for increasing resistance to etoposide

Mechanisms of resistance to VP‐16 were monitored in a series of sublines of the human testicular teratoma cell line (SuSa) derived following exposure either to fractionated X‐irradiation (DXR‐10) or to VP‐16 using pulsed 24‐hr exposures (VP 10) or continuous exposure conditions (VPC2, VPC3 and VPC4)...

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Veröffentlicht in:	International journal of cancer 1994-04, Vol.57 (2), p.259-267
Hauptverfasser:	Hosking, Louise K., Whelan, Richard D. H., Shellard, Sharon A., Davies, Sally L., Hickson, Ian D., Danks, Mary K., Hill, Bridget T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents ATP Binding Cassette Transporter, Subfamily B, Member 1 Biological and medical sciences Carrier Proteins - analysis Cell Survival - drug effects DNA - drug effects DNA Damage DNA Topoisomerases, Type II - analysis Drug Resistance Etoposide - metabolism Etoposide - pharmacology General aspects Humans Male Medical sciences Membrane Glycoproteins - analysis Pharmacology. Drug treatments Teratoma - pathology Testicular Neoplasms - pathology Tumor Cells, Cultured Verapamil - pharmacology Vincristine - metabolism
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