Aryl hydrocarbon hydroxylase activity in chemically induced and toremifene‐treated mammary tumors in rats

Aryl hydrocarbon hydroxylase (AHH) and NADPH‐cyto‐chrome P450 reductase (NCR) activity of microsomes from liver, lungs, uterus and mammary tumors in dimethylbenz‐antrachene‐induced and torem'rfene‐treated female Sprague‐Dawley rats were studied. AHH and NCR activity in tumors and uteri was low...

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Veröffentlicht in:	International journal of cancer 1994-01, Vol.56 (1), p.140-145
Hauptverfasser:	Pyykkö, Kaija, Ala‐Uotila, Sari, Jaakkola, Ulla‐Marjut, Lähde, Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	9,10-Dimethyl-1,2-benzanthracene Animal tumors. Experimental tumors Animals Aryl Hydrocarbon Hydroxylases - drug effects Aryl Hydrocarbon Hydroxylases - metabolism Biological and medical sciences Drug Screening Assays, Antitumor Experimental genital and mammary tumors Female Liver - drug effects Liver - enzymology Lung - drug effects Lung - enzymology Mammary Glands, Animal - drug effects Mammary Glands, Animal - enzymology Mammary Neoplasms, Experimental - chemically induced Mammary Neoplasms, Experimental - drug therapy Mammary Neoplasms, Experimental - enzymology Medical sciences NADPH-Ferrihemoprotein Reductase - drug effects NADPH-Ferrihemoprotein Reductase - metabolism Rats Rats, Sprague-Dawley Toremifene - therapeutic use Tumors Uterus - drug effects Uterus - enzymology
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