TGF‐β induces an inhibitory effect of normal cells directed against transformed cells

Co‐cultivation of normal and transformed fibroblasts in the presence of exogenously added transforming growth factor type beta 1 (TGF‐β1) leads to a drastic reduction of colony‐forming transformed cells. This inhibitory effect is dependent both on the dose of TGF‐β applied and the density of normal...

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Veröffentlicht in:	International journal of cancer 1993-04, Vol.54 (1), p.125-130
Hauptverfasser:	Höfler, P., Wehrle, I., Bauer, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Division - drug effects Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - drug effects Fundamental and applied biological sciences. Psychology In Vitro Techniques Mice Molecular and cellular biology Rats Transforming Growth Factor beta - pharmacology
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container_title	International journal of cancer
container_volume	54
creator	Höfler, P. Wehrle, I. Bauer, G.
description	Co‐cultivation of normal and transformed fibroblasts in the presence of exogenously added transforming growth factor type beta 1 (TGF‐β1) leads to a drastic reduction of colony‐forming transformed cells. This inhibitory effect is dependent both on the dose of TGF‐β applied and the density of normal cells. It does not reflect a direct action of TGF‐β on transformed cells, but is rather induced by TGF‐β in normal cells. In the absence of exogenously added TGF‐β, normal cells exhibit a basal inhibitory activity, which can be abrogated by anti‐TGF‐β. TGF‐β‐mediated inhibition of transformed cells by normal cells may be considered as a novel potent controlling step in carcinogenesis.
doi_str_mv	10.1002/ijc.2910540120
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Action of oncogenes and antioncogenes</topic><topic>Cell Transformation, Neoplastic - drug effects</topic><topic>Fundamental and applied biological sciences. 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subjects	Animals Biological and medical sciences Cell Division - drug effects Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - drug effects Fundamental and applied biological sciences. Psychology In Vitro Techniques Mice Molecular and cellular biology Rats Transforming Growth Factor beta - pharmacology
title	TGF‐β induces an inhibitory effect of normal cells directed against transformed cells
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