Bile acids, non‐phorbol‐ester‐type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29

Protein kinase C (PKC) is the target for a number of tumor promoters. The mechanism underlying the promoting effects of bile acids in colorectal cancer is not understood. We report that sodium deoxycholate (DOC) triggered activation of PKC in physiological conditions. The biphasic effects of DOC upo...

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