In vitro „education”︁ on autologous human sarcoma generates non‐specific killer cells
The cytotoxic effects mediated by lymphocytes from cancer patients after in vitro „education”︁ on autologous tumor cells have been investigated. Peripheral blood lymphocytes from three sarcoma patients were cultivated on autologous tumor‐cell monolayers and tested thereafter in a micro‐cytotoxicity...
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| Veröffentlicht in: | International journal of cancer 1975-02, Vol.15 (2), p.342-350 |
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| container_title | International journal of cancer |
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| creator | Martin‐Chandon, Marie‐Rose Vanky, Farkas Carnaud, Claude Klein, Eva |
| description | The cytotoxic effects mediated by lymphocytes from cancer patients after in vitro „education”︁ on autologous tumor cells have been investigated. Peripheral blood lymphocytes from three sarcoma patients were cultivated on autologous tumor‐cell monolayers and tested thereafter in a micro‐cytotoxicity assay against tumor and fibroblast cells. This procedure led to the progeny of non‐specific killer cells. As the phenomenon did not occur when the same lymphocytes were co‐cultivated with autologous fibroblasts, the generation of non‐specific effector cells may have been caused by specific antigenic triggering. The presence of autologous serum during „education”︁ was found to inhibit the manifestation and/or the generation of killer cells. The same serum was without effect when added during the cytotoxicity assay only. |
| doi_str_mv | 10.1002/ijc.2910150218 |
| format | Article |
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Peripheral blood lymphocytes from three sarcoma patients were cultivated on autologous tumor‐cell monolayers and tested thereafter in a micro‐cytotoxicity assay against tumor and fibroblast cells. This procedure led to the progeny of non‐specific killer cells. As the phenomenon did not occur when the same lymphocytes were co‐cultivated with autologous fibroblasts, the generation of non‐specific effector cells may have been caused by specific antigenic triggering. The presence of autologous serum during „education”︁ was found to inhibit the manifestation and/or the generation of killer cells. The same serum was without effect when added during the cytotoxicity assay only.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.2910150218</identifier><identifier>PMID: 1055101</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antigen-Antibody Reactions ; Biopsy ; Cells, Cultured ; Chondrosarcoma - immunology ; Culture Media ; Cytotoxicity Tests, Immunologic ; Fibrosarcoma - immunology ; Humans ; In Vitro Techniques ; Lymphocytes - immunology ; Neoplasm Transplantation ; Osteosarcoma - immunology ; Skin - pathology ; Transplantation, Autologous</subject><ispartof>International journal of cancer, 1975-02, Vol.15 (2), p.342-350</ispartof><rights>Copyright © 1975 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2558-815be40ec974fba613f4b0c0dfb6908f895a8820849483961fe42758a6efe35a3</citedby><cites>FETCH-LOGICAL-c2558-815be40ec974fba613f4b0c0dfb6908f895a8820849483961fe42758a6efe35a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.2910150218$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.2910150218$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1055101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin‐Chandon, Marie‐Rose</creatorcontrib><creatorcontrib>Vanky, Farkas</creatorcontrib><creatorcontrib>Carnaud, Claude</creatorcontrib><creatorcontrib>Klein, Eva</creatorcontrib><title>In vitro „education”︁ on autologous human sarcoma generates non‐specific killer cells</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>The cytotoxic effects mediated by lymphocytes from cancer patients after in vitro „education”︁ on autologous tumor cells have been investigated. Peripheral blood lymphocytes from three sarcoma patients were cultivated on autologous tumor‐cell monolayers and tested thereafter in a micro‐cytotoxicity assay against tumor and fibroblast cells. This procedure led to the progeny of non‐specific killer cells. As the phenomenon did not occur when the same lymphocytes were co‐cultivated with autologous fibroblasts, the generation of non‐specific effector cells may have been caused by specific antigenic triggering. The presence of autologous serum during „education”︁ was found to inhibit the manifestation and/or the generation of killer cells. The same serum was without effect when added during the cytotoxicity assay only.</description><subject>Antigen-Antibody Reactions</subject><subject>Biopsy</subject><subject>Cells, Cultured</subject><subject>Chondrosarcoma - immunology</subject><subject>Culture Media</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>Fibrosarcoma - immunology</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Lymphocytes - immunology</subject><subject>Neoplasm Transplantation</subject><subject>Osteosarcoma - immunology</subject><subject>Skin - pathology</subject><subject>Transplantation, Autologous</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1OwzAQhS0EKqWwZYfkC6SMkzixl6jip6gSG1iiyHHHJSWJKzsBdVduwAXgHJynF-AKpBQJdqxmpPe9t_gIOWYwZADhaTHXw1AyYBxCJnZIn4FMg-7nu6TfARCkLEr2yYH3cwDWYXGP9Bhw3nX65H5c06eicZauV-84bbVqCluvV2-fHy_U1lS1jS3tzLaePrSVqqlXTttK0RnW6FSDntYb_tUvUBem0PSxKEt0VGNZ-kOyZ1Tp8ejnDsjdxfnt6CqY3FyOR2eTQIeci0AwnmMMqGUam1wlLDJxDhqmJk8kCCMkV0KEIGIZi0gmzGAcplyoBA1GXEUDMtzuame9d2iyhSsq5ZYZg2yjKes0Zb-ausLJtrBo8wqnf_BvL10ut_lzUeLyn7VsfD36s_0FRvd4Nw</recordid><startdate>19750215</startdate><enddate>19750215</enddate><creator>Martin‐Chandon, Marie‐Rose</creator><creator>Vanky, Farkas</creator><creator>Carnaud, Claude</creator><creator>Klein, Eva</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19750215</creationdate><title>In vitro „education”︁ on autologous human sarcoma generates non‐specific killer cells</title><author>Martin‐Chandon, Marie‐Rose ; Vanky, Farkas ; Carnaud, Claude ; Klein, Eva</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2558-815be40ec974fba613f4b0c0dfb6908f895a8820849483961fe42758a6efe35a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Antigen-Antibody Reactions</topic><topic>Biopsy</topic><topic>Cells, Cultured</topic><topic>Chondrosarcoma - immunology</topic><topic>Culture Media</topic><topic>Cytotoxicity Tests, Immunologic</topic><topic>Fibrosarcoma - immunology</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Lymphocytes - immunology</topic><topic>Neoplasm Transplantation</topic><topic>Osteosarcoma - immunology</topic><topic>Skin - pathology</topic><topic>Transplantation, Autologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin‐Chandon, Marie‐Rose</creatorcontrib><creatorcontrib>Vanky, Farkas</creatorcontrib><creatorcontrib>Carnaud, Claude</creatorcontrib><creatorcontrib>Klein, Eva</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin‐Chandon, Marie‐Rose</au><au>Vanky, Farkas</au><au>Carnaud, Claude</au><au>Klein, Eva</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro „education”︁ on autologous human sarcoma generates non‐specific killer cells</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>1975-02-15</date><risdate>1975</risdate><volume>15</volume><issue>2</issue><spage>342</spage><epage>350</epage><pages>342-350</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>The cytotoxic effects mediated by lymphocytes from cancer patients after in vitro „education”︁ on autologous tumor cells have been investigated. Peripheral blood lymphocytes from three sarcoma patients were cultivated on autologous tumor‐cell monolayers and tested thereafter in a micro‐cytotoxicity assay against tumor and fibroblast cells. This procedure led to the progeny of non‐specific killer cells. As the phenomenon did not occur when the same lymphocytes were co‐cultivated with autologous fibroblasts, the generation of non‐specific effector cells may have been caused by specific antigenic triggering. The presence of autologous serum during „education”︁ was found to inhibit the manifestation and/or the generation of killer cells. The same serum was without effect when added during the cytotoxicity assay only.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1055101</pmid><doi>10.1002/ijc.2910150218</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0020-7136 |
| ispartof | International journal of cancer, 1975-02, Vol.15 (2), p.342-350 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Antigen-Antibody Reactions Biopsy Cells, Cultured Chondrosarcoma - immunology Culture Media Cytotoxicity Tests, Immunologic Fibrosarcoma - immunology Humans In Vitro Techniques Lymphocytes - immunology Neoplasm Transplantation Osteosarcoma - immunology Skin - pathology Transplantation, Autologous |
| title | In vitro „education”︁ on autologous human sarcoma generates non‐specific killer cells |
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