Carcinoma‐associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF‐2/FGFR‐2 axis

The mechanisms by which mammary carcinomas acquire hormone independence are still unknown. To study the role of cancer‐associated fibroblasts (CAF) in the acquisition of hormone‐independence we used a hormone‐dependent (HD) mouse mammary tumor and its hormone‐independent (HI) variant, which grows in...

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Veröffentlicht in:	International journal of cancer 2008-12, Vol.123 (11), p.2518-2531
Hauptverfasser:	Giulianelli, Sebastián, Cerliani, Juan P., Lamb, Caroline A., Fabris, Victoria T., Bottino, María C., Gorostiaga, María A., Novaro, Virginia, Góngora, Adrián, Baldi, Alberto, Molinolo, Alfredo, Lanari, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - pathology carcinoma associated fibroblasts Cell Proliferation - drug effects Cells, Cultured Coculture Techniques Female FGF receptors fibroblast growth factor 2 Fibroblast Growth Factor 2 - pharmacology Fibroblasts Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics hormone dependence Humans Mammary gland diseases Medical sciences Mice Mice, Inbred BALB C Progesterone - metabolism progesterone receptors and breast cancer Protein Binding Protein Kinase Inhibitors - pharmacology Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 2 - genetics Receptor, Fibroblast Growth Factor, Type 2 - metabolism Receptors, Progesterone - metabolism RNA, Small Interfering - genetics Signal Transduction - drug effects Tumors
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