Mutant p53 R270H gain of function phenotype in a mouse model for oncogene‐induced mammary carcinogenesis

In human breast cancer, mutations in the p53 gene are associated with poor prognosis. However, analysis of patient data so far did not clarify, whether missense point mutations in the p53 gene, in addition to causing loss of wild‐type p53 function, also confer a gain of function phenotype to the enc...

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Veröffentlicht in:	International journal of cancer 2008-04, Vol.122 (8), p.1701-1709
Hauptverfasser:	Heinlein, Christina, Krepulat, Frauke, Löhler, Jürgen, Speidel, Daniel, Deppert, Wolfgang, Tolstonog, Genrich V.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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