Anti‐metastatic effect of capecitabine on human colon cancer xenografts in nude mouse rectum

Capecitabine (N 4‐pentyloxycarbonyl‐5′‐deoxy‐5‐fluorocytidine) is a new fluoropyrimidine carbamate, which is converted to 5‐fluorouracil (5‐FU) by 3 sequential steps of enzyme reactions. We investigated the possibility of using capecitabine to prevent metastasis with a metastasis model of gastrointe...

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Veröffentlicht in:	International journal of cancer 2004-10, Vol.112 (1), p.135-142
Hauptverfasser:	Ninomiya, Itasu, Terada, Itsuro, Yoshizumi, Tetsuya, Takino, Takahisa, Nagai, Noboru, Morita, Akihiko, Fushida, Sachio, Nishimura, Genichi, Fujimura, Takashi, Ohta, Tetsuo, Miwa, Koichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites, Antineoplastic - therapeutic use Antineoplastic agents Biological and medical sciences Capecitabine Chemotherapy Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Fluorouracil - analogs & derivatives Gastrointestinal Neoplasms - prevention & control Gastrointestinal Neoplasms - secondary Green Fluorescent Proteins Humans Luminescent Proteins - metabolism lung metastasis Lung Neoplasms - prevention & control Lung Neoplasms - secondary lymph node metastasis Lymphatic Metastasis - prevention & control Male Medical sciences Mice Mice, Inbred BALB C Mice, Nude Pharmacology. Drug treatments Rectal Neoplasms - drug therapy Rectal Neoplasms - pathology rectal xenograft model Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism thymidine phosphorylase Thymidine Phosphorylase - genetics Thymidine Phosphorylase - metabolism Transplantation, Heterologous Tumors
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