Involvement of nucleophosmin/B23 in the response of HeLa cells to UV irradiation

The steady‐state mRNA level of nucleophosmin/B23 in HeLa cells increased after UV irradiation. Nucleophosmin/B23 antisense transfection potentiated ultraviolet (UV)‐induced cell killing. A block in G2/M phase, larger peak of apoptotic cells and higher caspase‐3 in vitro activity were noted in nucleo...

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Veröffentlicht in:	International journal of cancer 2002-01, Vol.97 (3), p.297-305
Hauptverfasser:	Wu, Ming H., Chang, Jei H., Chou, Chih C., Yung, Benjamin Y.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biological effects of radiation Caspase 3 Caspases - metabolism Chloramphenicol O-Acetyltransferase - metabolism DNA - radiation effects DNA Repair Dose-Response Relationship, Radiation Flow Cytometry Fundamental and applied biological sciences. Psychology Genes, Reporter Genetic Vectors - genetics Genetic Vectors - metabolism HeLa Cells Humans Immunoblotting Luciferases - metabolism Non ionizing radiations. Hertzian waves. Biooptics Nuclear Proteins - metabolism nucleophosmin/B23 Oligonucleotides, Antisense - pharmacology PCNA Plasmids - metabolism Proliferating Cell Nuclear Antigen - metabolism RNA - metabolism RNA, Messenger - metabolism Time Factors Tissues, organs and organisms biophysics Transfection Ultraviolet Rays
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