ASC/TMS1, a caspase‐1 activating adaptor, is downregulated by aberrant metylation in human melanoma

ASC/TMS1 is an adaptor protein activating caspase‐1 that stimulates processing of proIL‐1β and proIL‐18. ASC was reported to be aberrantly methylated and silenced in human breast cancers. In our present study, ASC expression was examined in 12 melanoma cell lines by Western blot analysis and in 18 b...

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Veröffentlicht in:	International journal of cancer 2003-11, Vol.107 (2), p.202-208
Hauptverfasser:	Guan, Xin, Sagara, Junji, Yokoyama, Taro, Koganehira, Yoko, Oguchi, Misae, Saida, Toshiaki, Taniguchi, Shun'ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	ASC CARD melanoma methylation PYD
Online-Zugang:	Volltext
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