A third‐generation matrix metalloproteinase (MMP) inhibitor (ONO‐4817) combined with docetaxel suppresses progression of lung micrometastasis of MMP‐expressing tumor cells in nude mice

The lung is the common target organ of hematogenous metastasis that restricts the prognosis of cancer patients. MMPs play a pivotal role in metastasis by promoting tumor invasion and angiogenesis; therefore, a large number of MMPIs have been developed. Our purpose was to determine the therapeutic ef...

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Veröffentlicht in:	International journal of cancer 2003-03, Vol.103 (6), p.822-828
Hauptverfasser:	Yamamoto, Akihiko, Yano, Seiji, Shiraga, Minoru, Ogawa, Hirohisa, Goto, Hisatsugu, Miki, Toyokazu, Zhang, Helong, Sone, Saburo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - prevention & control Adenocarcinoma - secondary Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - therapeutic use Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - prevention & control Carcinoma, Squamous Cell - secondary Chemotherapy combined therapy Drug Therapy, Combination film in situ zymography hematogenous metastasis Humans In Vitro Techniques Injections, Intravenous lung cancer Lung Neoplasms - enzymology Lung Neoplasms - pathology Lung Neoplasms - prevention & control Matrix Metalloproteinase Inhibitors Medical sciences Mice Mice, Nude Paclitaxel - analogs & derivatives Paclitaxel - therapeutic use Pharmacology. Drug treatments Phenyl Ethers - therapeutic use Survival Rate Taxoids
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